KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease (KNOW-CKD)
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ClinicalTrials.gov Identifier: NCT01630486 |
Recruitment Status :
Active, not recruiting
First Posted : June 28, 2012
Last Update Posted : June 5, 2019
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The goals of the KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease) study are 1) to establish a CKD cohort representing Korean CKD population for up to 10-year follow-up, and 2) to investigate the renal progression, mortality, complications, risk factors, role of biochemical parameters and the genetic influence.
KNOW-CKD Research Group comprises nephrologists, pediatric nephrologists, epidemiologists and statisticians from eleven centers in Korea. KNOW-CKD will enroll 2,850 individuals with CKD stage from 1 to 5 between 2011 and 2015 and follow them up to 10 years. Dialyzed patients or those with allograft kidney are excluded. At enrollment and at pre-specified intervals, laboratory tests will be conducted on the kidney function, biochemical profiles, anemia, cardiovascular complication (echocardiography, coronary CT, arterial stiffness), and mineral bone disorder. A biobank is also established for the DNA, serum and urine at regular interval. Information on the medical history, health questionnaires, QoL will also be collected. Web-based case-report forms (CRF) is developed for the systemic management of the patient data.
Condition or disease |
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Chronic Kidney Disease |
Study Type : | Observational |
Actual Enrollment : | 2238 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease |
Actual Study Start Date : | March 2011 |
Estimated Primary Completion Date : | December 2022 |
Estimated Study Completion Date : | December 2022 |

Group/Cohort |
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glomerulonephritis
adult CKD patients, whose underlying etiology is glomerulonephritis, either clinically diagnosed or pathologically proven
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hypertensive nephropathy
adult CKD patients, whose underlying etiology is hypertensive nephropathy
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polycystic kidney disease
adult CKD patients, whose underlying etiology is autosomal dominant polycystic kidney disease
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diabetic nephropathy
adult CKD patients, whose underlying etiology is diabetic nephropathy
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- overall mortality [ Time Frame: 10 years ]
- cardiovascular event [ Time Frame: 10 years ]
- renal replacement therapy [ Time Frame: 10 years ]dialysis or kidney transplantation
- doubling of serum creatinine [ Time Frame: 10 years ]
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 20 Years to 75 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Age: >20 and <75 yr,
- CKD stage 1 through 5
- predialysis
Exclusion Criteria:
- Unable or unwilling to give consent
- Previously received chronic dialysis
- Previous any organ transplant
- Heart failure
- Known liver cirrhosis
- past or current cancer
- Pregnant women
- Single kidney due to trauma or donation

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01630486
Korea, Republic of | |
Seoul National University Hospital | |
Seoul, Korea, Republic of, 110-744 |
Responsible Party: | Kook-Hwan Oh, Professor, Seoul National University Hospital |
ClinicalTrials.gov Identifier: | NCT01630486 |
Other Study ID Numbers: |
KNOW-CKD |
First Posted: | June 28, 2012 Key Record Dates |
Last Update Posted: | June 5, 2019 |
Last Verified: | June 2019 |
renal progression mortality complications |
risk factors role of biochemical parameters genetic influence |
Kidney Diseases Renal Insufficiency, Chronic Urologic Diseases Renal Insufficiency |