PRevention of Acute Kidney Injury Initiated With Electronic Surveillance Enhancement (PRAISE)
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|ClinicalTrials.gov Identifier: NCT01621152|
Recruitment Status : Active, not recruiting
First Posted : June 18, 2012
Last Update Posted : February 5, 2020
Introduction: Acute kidney injury (AKI) increases mortality, hospital cost, and rate of progression toward end stage kidney disease 1-4. Early diagnosis and management of AKI is known to improve the above mentioned outcomes.
Hypothesis: the investigators will design and validate an electronic surveillance tool to screen all the ICU admissions for the earlier, more efficient diagnosis of AKI and as a result improve the outcome of AKI in ICU patients.
Methods: the investigators plan to use the patient database, and AKIN (AKI network) definition to design an electronic alert system to allow clinicians discover patients who develop AKI. Then a randomized clinical trial will be conducted to compare earlier intervention (based on Kidney Disease: Improving Global Outcomes [KDIGO] guidelines) initiated by AKI sniffer alert to the conventional management provided by primary physician in ICU.
|Condition or disease||Intervention/treatment||Phase|
|Acute Kidney Injury||Other: Conventional management arm Other: AKI sniffer instigated AKI management||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||984 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Electronic Surveillance Sniffer for Early Detection and Intervention for Acute Kidney Injury: PRAISE Trial|
|Study Start Date :||June 2012|
|Estimated Primary Completion Date :||December 2021|
|Estimated Study Completion Date :||December 2023|
Conventional management arm
Patients with AKI receive standard of care in the conventional manner by the primary clinicians
Other: Conventional management arm
Based on KDIGO guidelines and as per primary physician in the ICU
Active Comparator: AKI sniffer instigated AKI management
primary clinicians for the AKI patients in this arm receive a verbal alert and reminder of KDIGO guidelines.
Other: AKI sniffer instigated AKI management
After identification of patients with AKI by the sniffer, primary physicians will be notified about the development of the syndrome and will be given a copy of the KDIGO guidelines for management of AKI.
- Change in acute kidney injury as measured by the Acute Kidney Injury Network Staging System [ Time Frame: baseline, 4 weeks ]The Acute Kidney Injury Network staging system is based on data indicating that a small change in serum creatinine influences outcome. Increases in serum creatinine or decreased urine output indicate greater kidney injury, with the stage ranging from 1 to 3. The higher the number, the greater the kidney injury.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01621152
|United States, Minnesota|
|Rochester, Minnesota, United States, 55905|
|Principal Investigator:||Kianoush Kashani, MD||Mayo Clinic|