Influence of Sodium Bicarbonate on Time-to-exhaustion at Critical Power in Endurance Athletes

• ClinicalTrials.gov Identifier: NCT01621074
• Recruitment Status: Completed
• First Posted: June 15, 2012
• Last Update Posted: April 12, 2013
• Sponsor: University of Zurich
• Collaborator: Swiss Federal Institute of Technology
• Information provided by (Responsible Party): University of Zurich

Study Description

Brief Summary:

During endurance exercise in the heavy and severe intensity domains, the rate at which metabolites that have been associated with the fatigue process (e.g. Pi, ADP, H, and extracellular K) accumulate increases. possibly leading to exercise cessation. Sodium bicarbonate, as a nutritional supplement, has gained attention over the past decades, because it might delay of offset fatigue. To date, there is a controversial discussion about which delivery mode (amount and frequency) might be best in optimizing endurance performance. Since the high ion load consequent to multiple ingestions might increase plasma volume, and consequently decrease bicarbonate concentrations, single acute ingestion could be more beneficial. However, in multi-day competitions or tournaments it might be necessary to use the supplement on a daily basis. Here, the investigators aim at investigating the effects of single dose or multiple dose (on five consecutive days) administration of bicarbonate vs. placebo increases endurance performance and acid-base homeostasis in trained male endurance athletes.

Condition or disease	Intervention/treatment	Phase
Performance	Dietary Supplement: Sodium bicarbonate; Dietary Supplement: Placebo	Not Applicable

Study Design

• Study Type: Interventional (Clinical Trial)
• Actual Enrollment: 12 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: Double (Participant, Outcomes Assessor)
• Study Start Date: October 2011
• Actual Primary Completion Date: August 2012
• Actual Study Completion Date: January 2013

Arms and Interventions

Arm	Intervention/treatment
Active Comparator: Sodium bicarbonate	Dietary Supplement: Sodium bicarbonate; Ergogenic effect
Placebo Comparator: Placebo	Dietary Supplement: Placebo; Placebo effect

Outcome Measures

Primary Outcome Measures :

1. Time-to-exhaustion [ Time Frame: 5 weeks ]

Eligibility Criteria

• Ages Eligible for Study: 18 Years to 45 Years (Adult)
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: No

Criteria

Inclusion criteria: - male

• no cold or temperature at beginning or during the study
• between 18 and 45 years of age
• active in endurance sports (3 to 5 times per week a moderate to hart training)
• non-smoker
• no known cardiovascular or orthopedic problems
• no known limitations of kidney function
• no bearer of a cardiac pacemaker
• no medications with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
• requirements of the health questionnaire fulfilled

Exclusion criteria: - female

• male and age under 18 or over 45 years
• cold or temperature at the beginning or during the study
• untrained (less than 3 moderate trainings per week)
• smoker
• cardiovascular or orthopedic problems
• limitations of the kidney function
• bearer of a cardiac pacemaker
• medication with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
• requirements of the health questionnaire not fulfilled

Contacts and Locations

Locations

Switzerland

University Hospital Zurich, Division of Neurology

Zurich, ZH, Switzerland, 8091

Sponsors and Collaborators

University of Zurich

Swiss Federal Institute of Technology

Investigators

• Study Director: Neurologie: Neurologische Forschung; University Hospital Zurich, Division of Neurology
• Principal Investigator: Marco Toigo, PhD; Swiss Federal Institute of Technology Zurich

More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Mueller SM, Gehrig SM, Frese S, Wagner CA, Boutellier U, Toigo M. Multiday acute sodium bicarbonate intake improves endurance capacity and reduces acidosis in men. J Int Soc Sports Nutr. 2013 Mar 26;10(1):16. doi: 10.1186/1550-2783-10-16.

• Responsible Party: University of Zurich
• ClinicalTrials.gov Identifier: NCT01621074
• Other Study ID Numbers: nbc
• First Posted: June 15, 2012
• Last Update Posted: April 12, 2013
• Last Verified: April 2013