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Stress Echocardiography Versus Coronary Angiography for Left Main Stenosis Detection (ESTRIE-TC)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01620320
Recruitment Status : Withdrawn (No Funding)
First Posted : June 15, 2012
Last Update Posted : June 26, 2013
Information provided by (Responsible Party):
Paul Farand, Université de Sherbrooke

Brief Summary:
Left main stenosis use to be treated by bypass but with the improvement of angioplasty techniques, an increasing number of patients are submit to left main coronary angioplasty. Consequences of left main intra stent stenosis can be disastrous yet, for the moment, no precise recommendation concerning the follow up of these patients exist. The investigators ought to determine if stress echocardiography can predict left main intra stent stenosis as well (non inferiorly)as control angiography that use to be done.

Condition or disease Intervention/treatment
Left Main Coronary Artery Disease Stenosis Other: Stress echocardiography

Detailed Description:
All patients of the study will pass coronary angiogram and stress echocardiography (treadmill of dobutamine).

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Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Évaluation de l'Echographie de Stress Par Comparaison à la Coronarographie Comme Outil Non Invasif de détection de la resténose Intra endoprothèse du Tronc Commun
Study Start Date : July 2010
Estimated Primary Completion Date : July 2012
Estimated Study Completion Date : July 2013

Resource links provided by the National Library of Medicine

Drug Information available for: Dobutamine

Group/Cohort Intervention/treatment
Stress echography
Nine to twelve months after their left main angioplasty, patients will go through a stress echo and then the usual control angiography (done routinely in most patient in our center). Patients will act as their own control.
Other: Stress echocardiography
Patients able to exercise will have a treadmill test + echography; the others will have a dobutamine echography.
Other Names:
  • Dobutamine echocardiography
  • Treadmill echocardiography

Primary Outcome Measures :
  1. Correlation between stress echocardiography results for the detection of left main prosthesis stenosis with coronary angiogram results. [ Time Frame: 9 to 12 months after left main angioplasty ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients presenting to teaching hospital or stent from community hospitals to teaching hospital and having left main angioplasty

Inclusion Criteria:

  • patients over 18 years old able to give consent and having had left main angioplasty.

Exclusion Criteria:

  • Bypass on the left anterior descending coronary artery or left circumflex (" protected left main ")
  • Treating physician judge that angiography need to be done straightaway
  • Follow up elsewhere than the CHUS
  • Patient refusal
  • Pregnant women
  • Stress echo contraindication(Severe high blood pressure or malignant arrhythmia)or condition that limits interpretation (Left bundle branch block or pacemaker rhythm)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01620320

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Canada, Quebec
Centre Hospitalier Universitaire de Sherbrooke, departement de cardiologie
Sherbrooke, Quebec, Canada, J1H 5N4
Sponsors and Collaborators
Université de Sherbrooke
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Principal Investigator: Paul Farand, Cardiologue Centre de recherche du Centre hospitalier universitaire de Sherbrooke

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Responsible Party: Paul Farand, Doctor, Université de Sherbrooke Identifier: NCT01620320    
Other Study ID Numbers: projet #10-011
First Posted: June 15, 2012    Key Record Dates
Last Update Posted: June 26, 2013
Last Verified: June 2013
Keywords provided by Paul Farand, Université de Sherbrooke:
Left main coronary artery
Coronary artery disease
Stress echography
Intrastent stenosis
Additional relevant MeSH terms:
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Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Constriction, Pathologic
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
Pathological Conditions, Anatomical
Cardiotonic Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Adrenergic beta-1 Receptor Agonists
Adrenergic beta-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Protective Agents