Lean Muscle Function (LEAN)
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|ClinicalTrials.gov Identifier: NCT01616498|
Recruitment Status : Completed
First Posted : June 11, 2012
Last Update Posted : March 14, 2017
|Condition or disease|
|Single Muscle Fibers|
|Study Type :||Observational|
|Actual Enrollment :||24 participants|
|Official Title:||Obesity and Muscle Function Pilot Study|
|Study Start Date :||June 2012|
|Actual Primary Completion Date :||September 2013|
|Actual Study Completion Date :||November 2013|
Comparison data from this lean cohort will be compared to the obese older adults are already being collected in an R01-funded study (Improving Muscle for Functional Independence Trial; IRB00009098; NCT01049698)
- Muscle Fiber [ Time Frame: Baseline ]
To measure single muscle fiber contractile properties, including specific force, unloaded shortening velocity, and maximum power. We will also measure whole muscle strength and size and fiber fat infiltration. These results will establish a reference database against which data recorded in older obese individuals can be compared.
Primary hypothesis: Single muscle fibers will exhibit more force and power in healthy non-obese than obese older adults due to greater intra-myocellular fat infiltration.
- Muscle Strength [ Time Frame: Baseline ]Non-obese older adults will exhibit greater whole muscle strength (absolute and relative to muscle mass and volume) and power than obese, older adults.
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01616498
|United States, North Carolina|
|Wake Forest University Health Sciences|
|Winston Salem, North Carolina, United States, 27157|
|Principal Investigator:||Barbara Nicklas, PhD||Wake Forest University Health Sciences|