Meta-analysis of Fructose-Containing Sugar Sweetened Beverages (SSBs) and Weight Change
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ClinicalTrials.gov Identifier: NCT01608607 |
Recruitment Status : Unknown
Verified May 2015 by John Sievenpiper, University of Toronto.
Recruitment status was: Active, not recruiting
First Posted : May 31, 2012
Last Update Posted : May 27, 2015
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Condition or disease | Intervention/treatment |
---|---|
Overweight Obesity Diabetes Prediabetes Dysglycemia Metabolic Syndrome | Other: Fructose-containing sugar sweetened beverages |

Study Type : | Observational |
Actual Enrollment : | 1 participants |
Time Perspective: | Prospective |
Official Title: | Effect of Fructose-containing Sugar Sweetened Beverages (SSBs) on Body Weight: A Systematic Review and Meta-analysis of Controlled Feeding Trials to Provide Evidence-based Guidance for Nutrition Guidelines Development |
Study Start Date : | May 2012 |
Actual Primary Completion Date : | September 2014 |
Estimated Study Completion Date : | October 2015 |

- Other: Fructose-containing sugar sweetened beverages
Oral dietary fructose-containing sugar sweetened beverages in isocaloric exchange for other sources of carbohydrate (isocaloric trials) or hypercaloric exchange for beverages containing a non-nutritive sweetener or added to a control diet as a source of excess energy (hypercaloric trials)
- Body weight [ Time Frame: 1.5-years ]

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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- Trials in humans
- Oral fructose intervention
- Suitable control (i.e. another carbohydrate source in isocaloric exchange for fructose or a control diet which is compared with the same diet supplemented with excess energy from fructose)
- >= 7-days diet duration
- Viable endpoint data
Exclusion Criteria:
- Non-human studies
- IV or parenteral fructose
- High fructose corn syrup or sucrose intervention (except where these are the comparators)
- Lack of a suitable control
- < 7-days diet duration.
- No viable endpoint data

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01608607
Canada, Ontario | |
The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Micheal's Hospital | |
Toronto, Ontario, Canada, M5C 2T2 |
Study Director: | John L Sievenpiper, MD, PhD | Department of Pathology and Molecular Medicine, McMaster University and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital | |
Study Director: | Russell J de Souza, ScD, RD | Department of Epidemiology and Biostatistics, McMaster University and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital | |
Principal Investigator: | David JA Jenkins, MD, PhD, DSc | Department of Nutritional Sciences and Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital |
Responsible Party: | John Sievenpiper, Adjunct Research Fellow, University of Toronto |
ClinicalTrials.gov Identifier: | NCT01608607 |
Other Study ID Numbers: |
CCC 2012 KRS |
First Posted: | May 31, 2012 Key Record Dates |
Last Update Posted: | May 27, 2015 |
Last Verified: | May 2015 |
Systematic review and meta-analysis Evidence-based medicine (EBM) Evidence-based nutrition (EBN) Clinical practice guidelines Clinical trials Dietary sugars Fructose High fructose corn syrup |
sucrose Isocaloric Hypercaloric Glycemic control Insulin resistance Body weight body mass index waist circumference |
Metabolic Syndrome Overweight Body Weight Insulin Resistance |
Hyperinsulinism Glucose Metabolism Disorders Metabolic Diseases |