COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH:
Working… Menu

Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01595373
Recruitment Status : Completed
First Posted : May 10, 2012
Last Update Posted : January 16, 2013
Information provided by (Responsible Party):
Esben Thyssen Vestergaard, University of Aarhus

Brief Summary:
The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.

Condition or disease Intervention/treatment Phase
Healthy Drug: Acyl ghrelin Drug: Placebo (Ringer acetate) Early Phase 1

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 10 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Local Metabolic Effects of Ghrelin: A Clinical Microdialysis Study
Study Start Date : June 2012
Actual Primary Completion Date : September 2012
Actual Study Completion Date : January 2013

Arm Intervention/treatment
Active Comparator: Ghrelin
Drug: Acyl ghrelin
Acyl ghrelin 12.5 pg/min infused continuously for 300 minutes
Other Names:
  • Human acyl ghrelin
  • Ghrelin

Placebo Comparator: Placebo
Ringer acetate is used for placebo.
Drug: Placebo (Ringer acetate)
Ringer acetate 2 microliter/min for 300 minutes

Primary Outcome Measures :
  1. Interstitial concentrations of glycerol [ Time Frame: Interstitial concentrations of glycerol at t=120 minutes ]

Secondary Outcome Measures :
  1. Interstitial concentrations of lactate [ Time Frame: Interstitial concentrations of lactate at t=120 minutes ]
  2. Interstitial concentrations of glucose [ Time Frame: Interstitial concentrations of glucose at t=120 minutes ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy male
  • age 18-65 years (included)
  • Body mass index 20-25 (included)

Exclusion Criteria:

  • alcohol abuse
  • malignant disease
  • use of any medicine except otc painkillers
  • any disease recognized
  • participation in a trial using radioactive isotopes within the last 6 months

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01595373

Layout table for location information
Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
Esben Thyssen Vestergaard
Layout table for investigator information
Principal Investigator: Esben T. Vestergaard, MD PhD University of Aarhus
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information
Responsible Party: Esben Thyssen Vestergaard, Postdoc PhD, University of Aarhus Identifier: NCT01595373    
Other Study ID Numbers: 2012-28512
First Posted: May 10, 2012    Key Record Dates
Last Update Posted: January 16, 2013
Last Verified: January 2013
Keywords provided by Esben Thyssen Vestergaard, University of Aarhus:
Metabolic effects of ghrelin