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Hereditary Haemorrhagic Telangiectasia Flight Safety Study (Flying and HHT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01590121
Recruitment Status : Completed
First Posted : May 2, 2012
Last Update Posted : May 29, 2015
Information provided by (Responsible Party):
Imperial College London

Brief Summary:

Hereditary Haemorrhagic Telangiectasia (HHT) is a condition in which sufferers have abnormal blood vessels which makes them more likely to bleed than other people, particularly in the lungs, which results in low blood oxygen levels. Flying may make this worse and cause problems. The investigators want to know if there are an increased number of problems on flights compared to on land.

The investigators currently do not have any evidence based guidelines on air travel to best advice people who suffer with HHT. The investigators would therefore like to ask individuals who have HHT about their experience on a flight, using a postal questionnaire.

Condition or disease Intervention/treatment
Hereditary Haemorrhagic Telangiectasia Other: Aeroplane flight in the past- no active intervention for study Other: Questionnaire

Detailed Description:

Individuals with Hereditary Haemorrhagic Telangiectasia (HHT) previously reviewed at HHTIC London will be sent an invitation to participate in a short questionnaire study.

Quantitative variables from the questionnaires for statistical analysis will be the number of individuals responding (and number of questionnaires sent out); number of flights taken and number of complications, subgrouped by type, and flight duration in hours. Complication rates will be expressed as proportion of person flight hours.

The quantitative data from the questionnaire will then be compared with quantitative data from patients' medical records using non parametric methods such as Mann Whitney for univariate analyses.

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Study Type : Observational
Actual Enrollment : 145 participants
Time Perspective: Retrospective
Official Title: A Questionnaire Based Study to Evaluate the Safety of Flying in Hereditary Haemorrhagic Telangiectasia (HHT)
Study Start Date : January 2010
Actual Primary Completion Date : October 2011
Actual Study Completion Date : October 2011

Group/Cohort Intervention/treatment
Pateints with hereditary haemorrhagic telangiectasia Other: Aeroplane flight in the past- no active intervention for study
Aeroplane flight(s) previously taken by study participants

Other: Questionnaire
Flight by aeroplane (previous)

Primary Outcome Measures :
  1. Self reported medical complication [ Time Frame: During or in 6 weeks post flight ]

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
HHT patients previously assesses at Hammersmith Hospital, England

Inclusion Criteria:


Exclusion Criteria:

Unable to provide informed consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01590121

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United Kingdom
HammersmithHospital, Imperial College Healthcare NHS Trust
London, United Kingdom, W12 0NN
Sponsors and Collaborators
Imperial College London
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Principal Investigator: Claire L Shovlin, PhD MA MB BChir FRCP Imperial College London

Publications of Results:
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Responsible Party: Imperial College London Identifier: NCT01590121     History of Changes
Other Study ID Numbers: CLS/20
First Posted: May 2, 2012    Key Record Dates
Last Update Posted: May 29, 2015
Last Verified: April 2012
Keywords provided by Imperial College London:
Previous flight by aeroplane
Additional relevant MeSH terms:
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Telangiectasia, Hereditary Hemorrhagic
Vascular Diseases
Cardiovascular Diseases
Hemostatic Disorders
Hemorrhagic Disorders
Hematologic Diseases
Vascular Malformations
Cardiovascular Abnormalities
Congenital Abnormalities