Impact of Impaired Cerebral Autoregulation on Postoperative Delirium in Elderly Patients Undergoing Spine Surgery
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ClinicalTrials.gov Identifier: NCT01574950 |
Recruitment Status :
Completed
First Posted : April 10, 2012
Last Update Posted : October 26, 2015
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Condition or disease |
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Delirium |
Study Type : | Observational |
Actual Enrollment : | 99 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | The Impact of Impaired Cerebral Autoregulation on the Development of Postoperative Delirium in Elderly Patients Undergoing Spine Surgery |
Study Start Date : | March 2012 |
Actual Primary Completion Date : | June 2014 |
Actual Study Completion Date : | June 2014 |
- Incidence of post-operative delirium in elderly patients undergoing spine surgery at Johns Hopkins Hospital [ Time Frame: 24 months ]
- Severity of postoperative delirium, using Delirium Rating Scale-Revised-1998, in elderly patients undergoing spine surgery. [ Time Frame: 24 months ]
Biospecimen Retention: Samples Without DNA

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Ages Eligible for Study: | 70 Years and older (Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- ≥ 70 years old,
- Undergoing any lumbar spine surgery, posterior cervical spine surgery, or anterior cervical spine surgery > 2 levels
Exclusion Criteria:
- MMSE < 15
- Delirium at baseline
- Inability to speak and understand English
- Severe hearing impairment, resulting in inability to converse.
- Planned use of intraoperative ketamine
- Planned use of intraoperative remifentanil, except for airway management pre-incision.
- Arterial catheter not planned to be inserted

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01574950
United States, Maryland | |
The Johns Hopkins University | |
Baltimore, Maryland, United States, 21287 |
Principal Investigator: | Charles Brown, MD | The Johns Hopkins University |
Responsible Party: | Charles Brown, MD, Principal Investigator, Johns Hopkins University |
ClinicalTrials.gov Identifier: | NCT01574950 |
Other Study ID Numbers: |
NA_00051796 |
First Posted: | April 10, 2012 Key Record Dates |
Last Update Posted: | October 26, 2015 |
Last Verified: | October 2015 |
Delirium |
Delirium Confusion Neurobehavioral Manifestations Neurologic Manifestations |
Nervous System Diseases Neurocognitive Disorders Mental Disorders |