The Pharmaco-genetic and Brain Mechanisms Associated With Cannabis- Induced Psychosis
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|ClinicalTrials.gov Identifier: NCT01565174|
Recruitment Status : Unknown
Verified April 2012 by VEINSHTEIN AVIV, Hadassah Medical Organization.
Recruitment status was: Not yet recruiting
First Posted : March 28, 2012
Last Update Posted : April 3, 2012
|Condition or disease|
|Cannabis Dependence Psychosis|
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||The Pharmaco-genetic and Brain Mechanisms Associated With Cannabis- Induced Psychosis|
|Study Start Date :||October 2012|
|Estimated Primary Completion Date :||October 2014|
|Estimated Study Completion Date :||October 2014|
High activity COMT
Carriers of high activity COMT158Val allele who are expected to show higher THC-induced meso-limbic DA release
Low activity COMT
Carriers of low activity COMT 158Met homozygotes are expected to release low amount of dopamine after smoking a cigarette with THC
- Genetic variations of Dopamine, GABA, glutamate, cannabis CB1 receptor [ Time Frame: 2 years ]DNA will be extracted from saliva of participants. Genetic variations of DA, GABA, glutamate and cannabis receptor CB1 will be coded.
- Measures of dopamine D2 receptor occupancy before and after smoking a cigarette containing THC. [ Time Frame: 2 years ]Participants will be studied in a brain imaging study using [C 11] raclopride radioligand in Positron Emission Tomography (PET). Measures of D2 receptor occupancy will be taken at baseline and after smoking a cigarette containing 15 mg THC.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01565174
|Contact: Aviv M Weinstein, Ph.Demail@example.com|
|Contact: Roland Chisin, M.Dfirstname.lastname@example.org|
|Hadassah Medical Organization, Jerusalem, Israel|
|Jerusalem, Israel, 91120|
|Contact: Hadas Lemberg, Ph.D 00 972 2 6777572 email@example.com|
|Principal Investigator: Aviv M Weinstein, Ph.D|
|Principal Investigator:||Aviv Weinstein, Ph.D||Hadassah Medical Organization|