Cardiovascular-Renal Consequences of Reducing Renal Mass After Living Kidney Donation
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01564966|
Recruitment Status : Completed
First Posted : March 28, 2012
Last Update Posted : March 29, 2012
- A reduce in renal mass may result in remnant single nephron hyperfiltration, with associated proteinuria and an accelerated loss of kidney function.
- Live-donor kidney transplantation is generally considered the best choice for patients who have renal failure and are awaiting transplantation, because these kidneys function better than kidneys from deceased donors, and waiting times for deceased-donor transplants are long
- Although several studies have shown that kidney donation has low short-term morbidity and mortality, the data on long-term outcomes are much less complete.
- This study is designed to prospectively evaluate the effects of unilateral nephrectomy on cardiovascular-renal functions of donors after living kidney donation: the development of hypertension, albuminuria, renal failure, inflammatory and endothelial changes.
|Condition or disease|
|Kidney Failure Hypertension Albuminuria Renal Failure Inflammation Endothelial Dysfunction|
Renal dysfunction is associated with accelerated cardiovascular disease even when kidney function is only mildly impaired. Besides, even levels of urinary albumin excretion below the accepted threshold for microalbuminuria are associated with increased cardiovascular risk, and the risk increases as the degree of proteinuria rises.
- Live-donor kidney transplantation is generally considered the best choice for patients who have renal failure and are awaiting transplantation, because these kidneys function better than kidneys from deceased donors, and waiting times for deceased-donor transplants are long. Although several studies have shown that kidney donation has low short-term morbidity and mortality, the data on long-term outcomes are much less complete. The short and long term renal functions of donors after kidney donation were much studied and still remain uncertain, the cardiovascular effects of reduction in renal mass in kidney donors is also not clearly known.
- Endothelial dysfunction (ED) is the first step for subsequent development of atherosclerosis, which can help us to assess the cardiovascular changes after kidney donation. Prospectively examining the endothelial consequences of uninephrectomy in donors may provide useful insight into the existence and pathophysiology of cardiovascular disease in donors and, therefore, into how the cardiovascular disease risk associated with renal impairment might eventually be reduced.
|Study Type :||Observational|
|Actual Enrollment :||46 participants|
|Official Title:||Cardiovascular-Renal Consequences of Reducing Renal Mass After Living Kidney Donation|
|Study Start Date :||April 2008|
|Actual Primary Completion Date :||September 2011|
|Actual Study Completion Date :||December 2011|
Living kidney donors
Those who donate kidneys
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01564966
|Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University|
|Istanbul, Turkey, 34093|
|Study Director:||Alaattin Yildiz, Professor of Medicine, MD||Istanbul University, Istanbul Faculty of Medicine|