Magnesium is Associated With QoL in COPD: A Cross-sectional Study
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|ClinicalTrials.gov Identifier: NCT01564953|
Recruitment Status : Completed
First Posted : March 28, 2012
Results First Posted : March 6, 2017
Last Update Posted : March 6, 2017
|Condition or disease|
|Chronic Obstructive Pulmonary Disease (COPD)|
Attention is enhancing worldwide on the increasing tendency of insufficient 25-hydroxyvitamin D serum levels. New insights into the role of vitamin D and distribution of its receptors in the human body have been revealed. Presumably, this entails implications concerning disease and treatment that go far beyond the well-known field of bone-metabolism.
Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), and reductions in vitamin D serum levels have formerly been perceived as a consequence rather than a cause of COPD.
Yet, there is a lack of consensus concerning the role of vitamin D on the decreasing lung function in COPD.
Some trials have revealed a high degree of co-variation between the grade of airway obstruction, intake of vitamin D and reduction of serum-vitamin D. Other claim that vitamin D appears to be capable of inhibiting pulmonary inflammatory responses.
Vitamin D interacts with calcium and magnesium and this subtle balance might be highly relevant in the progression of inflammatory diseases like COPD. Presumably, Mg inhibits contraction and relaxes smooth muscles in airways due to blocking of calcium-ion-flux across the cell membrane.
The aim of this study is to investigate the status of vitamin D, magnesium and calcium in COPD, and to study the relationship and impact of vitamin D, magnesium and calcium in COPD-patients.
The hypothesis of this study is that COPD-patients with vitamin D-, magnesium- and calcium supplement have a better lung function and quality of life, than those who have vitamin D-, magnesium- and calcium deficiency.
|Study Type :||Observational|
|Actual Enrollment :||143 participants|
|Official Title:||Serum Magnesium and Nit Vitamin D is Associated With Better QoL in COPD: A Cross-sectional Study|
|Study Start Date :||February 2012|
|Actual Primary Completion Date :||October 2012|
|Actual Study Completion Date :||January 2013|
- Serum Vitamin D [ Time Frame: one year ]vitamin D measured by p-25-hydroxy-vitamin D2 + D3, in mmol/L
- Lung Function Test [ Time Frame: one year ]Forced expiratory ventilation in 1 second, in percent of predicted
- Serum Magnesium [ Time Frame: One year ]Serum magnesium in plasma, in mmol/L
- Serum Calcium [ Time Frame: One year ]Serum ionized calcium, in mmol/L
- Quality of Life [ Time Frame: One year ]Quality of life measured by Chronic Obstructive Pulmonary Disease Assesment Test. Minimum score was 0 (no symptoms) and maximum score was 40 (many symptoms).
Biospecimen Retention: Samples Without DNA
p-creatinine p-potassium p-sodium p-albumine p-phosphate p-magnesium p-calcium-ion p-parathyrine p-25-hydroxy-vitamin D2 + D3
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01564953
|Aarhus University Hospital|
|Aarhus, Denmark, 8000|
|Study Director:||Ronald Dahl, Professor||Allergy Centre, Odense University Hospital|
|Principal Investigator:||Sarah HA Hussein, MD||Department of Respiratory Diseases, Aarhus University Hospital|