COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH:
Working… Menu

Insecticidal School Uniforms for Dengue Prevention in Thailand (DengueTools)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01563640
Recruitment Status : Terminated (Insecticidal treatment of school uniforms did not last through a dengue season)
First Posted : March 27, 2012
Last Update Posted : September 1, 2015
European Union
Information provided by (Responsible Party):
Peter Byass, Umeå University

Brief Summary:
This is a randomised controlled trial that will be conducted in eastern Thailand in a group of schools with approximately 2,000 students aged 7-15 years. Pre-fabricated school uniforms will be commercially treated to ensure consistent high quality of insecticide impregnation with permethrin. A double-blind randomised cross-over trial at the school level will cover two dengue transmission seasons.

Condition or disease Intervention/treatment Phase
Dengue Other: permethrin insecticide Other: washing Not Applicable

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 1825 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Can Insecticide-treated School Uniforms Reduce Dengue Infections in School-aged Children in Thailand
Study Start Date : March 2012
Actual Primary Completion Date : June 2013
Actual Study Completion Date : December 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Dengue
Drug Information available for: Permethrin

Arm Intervention/treatment
Placebo Comparator: normal school uniforms
washing only
Other: washing
normal washing of school uniforms, without permethrin insecticide impregnation

Experimental: insecticide-treated school uniforms
washing and insecticide treatment
Other: permethrin insecticide
commercial permethrin insecticide impregnation of clothing before transmission season

Primary Outcome Measures :
  1. insecticide:placebo incidence rate-ratio (per 1,000 person-years) of laboratory-confirmed dengue cases in school-aged children [ Time Frame: up to 2 years ]
    Schools are cross-over randomised to insecticide-treated or untreated (placebo) school uniforms, and so the primary outcome is the rate-ratio of dengue fever cases in school children, compared between these two groups.

Secondary Outcome Measures :
  1. comparison between intervention and placebo groups of number of serious skin reactions to insecticide-treated uniforms [ Time Frame: up to 2 years ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   7 Years to 15 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • pupils in participating schools

Exclusion Criteria:

  • skin sensitivity, exema

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01563640

Layout table for location information
Centre of Excellence for Vectors and Vector-Borne Diseases, Mahidol University
Salaya, Thailand
Sponsors and Collaborators
Umeå University
European Union
Layout table for investigator information
Principal Investigator: Annelies Wilder-Smith, MD Umeå University
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information
Responsible Party: Peter Byass, Professor of Global Health, Umeå University Identifier: NCT01563640    
Other Study ID Numbers: 282589-T
First Posted: March 27, 2012    Key Record Dates
Last Update Posted: September 1, 2015
Last Verified: August 2015
Keywords provided by Peter Byass, Umeå University:
Additional relevant MeSH terms:
Layout table for MeSH terms
Arbovirus Infections
Virus Diseases
Flavivirus Infections
Flaviviridae Infections
RNA Virus Infections
Hemorrhagic Fevers, Viral
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action