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Glucose as a Mediator of Self-control Performances in Patients With Schizophrenia

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ClinicalTrials.gov Identifier: NCT01563016
Recruitment Status : Unknown
Verified March 2012 by The University of Hong Kong.
Recruitment status was:  Not yet recruiting
First Posted : March 26, 2012
Last Update Posted : March 26, 2012
Sponsor:
Collaborator:
Queen Mary Hospital, Hong Kong
Information provided by (Responsible Party):
The University of Hong Kong

Study Description
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Brief Summary:

The research aims to investigate the relationship between self-control ability and blood glucose level in schizophrenic patients. The main purpose of the present study is to explore whether the close relationship of blood glucose and self-regulatory strength observed in healthy individuals, is applicable to schizophrenic patients. More specifically, the current study aims

  • to investigate whether the exertion of self-control reduces blood glucose,
  • to examine whether low level of blood glucose deteriorates subsequent self-control performances
  • to examine whether restoring the glucose level eliminates these impairments, in schizophrenic patients.

Condition or disease Intervention/treatment Phase
Schizophrenia Dietary Supplement: glucose drink Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Glucose as a Mediator of Self-control Performances in Patients With Schizophrenia: A Randomized Controlled Study
Study Start Date : April 2012
Estimated Primary Completion Date : April 2013
Estimated Study Completion Date : April 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia
Drug Information available for: Dextrose

Arms and Interventions
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Arm Intervention/treatment
Experimental: Glucose & Depleting
participants will perform in a depleting task and receive a glucose drink
 Dietary Supplement: glucose drink
participants will receive a drink rich in glucose
Placebo Comparator: Glucose & non-depleting
participants will perform in a non-depleting task and receive a glucose drink
 Dietary Supplement: glucose drink
participants will receive a drink rich in glucose
No Intervention: Placebo & depleting
participants will perform in a depleting task and receive a placebo drink
No Intervention: Placebo & non depleting
participants will perform in a non depleting task and receive a placebo drink


Outcome Measures
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Primary Outcome Measures :
  1. Blood Glucose Level [ Time Frame: baseline, after depleting task ]
  2. self control tasks (handgrip, stroop, figure tracing task) [ Time Frame: after 12-minutes metabolizing phase ]

Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   15 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Aged 15 or above
  • DSM-IV diagnosis of schizophrenia, schizoaffective disorder, schizophreniform psychosis, brief psychosis, psychosis NOS or delusional disorder
  • Cantonese-speaking Chinese
  • Ability to understand the nature of the study and sign informed consent

Exclusion Criteria:

  • Organic Brain disorder
  • Known history of intellectual disability
  • Priority Follow Up (Subtarget or Target)
  • All allergic to any sugar or artificial sweeteners
  • Diabetics
  • Physical Disability
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01563016


Contacts
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Contact: Eric YH Chen, MD 852-22553063 eyhchen@hku.hk
Contact: Chung-Ming Leung, Bsc 852-64054460 mingming4f29@hotmail.com

Locations
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China
The University of Hong Kong
Hong Kong, China
Contact: Bonnie Choi       bwschoi@hku.hk   
Sponsors and Collaborators
The University of Hong Kong
Queen Mary Hospital, Hong Kong
Investigators
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Principal Investigator: Eric YH Chen, MD The University of Hong Kong
More Information
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Responsible Party: The University of Hong Kong
ClinicalTrials.gov Identifier: NCT01563016    
Other Study ID Numbers: selfcontrolvsglucose
First Posted: March 26, 2012    Key Record Dates
Last Update Posted: March 26, 2012
Last Verified: March 2012
Keywords provided by The University of Hong Kong:
schizophrenia
Psychotic Disorders
Psychoses
Additional relevant MeSH terms:
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Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders