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Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment

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ClinicalTrials.gov Identifier: NCT01559766
Recruitment Status : Completed
First Posted : March 21, 2012
Last Update Posted : March 21, 2012
Sponsor:
Collaborators:
ShiYan Centre for Disease Control and Prevention
Tufts Medical Center
Information provided by (Responsible Party):
Xiufa Sun, Huazhong University of Science and Technology

Study Description
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Brief Summary:
Vitamin A deficiency remains a major public health problem in developing country worldwide. Young Children are considered to be at greatest risk of deficiency. However, there is little information on the vitamin A requirement of Chinese children. In the present study, about 400 children aged between 4 and 9 years old in a kindergarten and an elementary school of Shiyan City were screened before admission by questionnaire and anthropometric measurement. The vitamin A status of children was assessed by serum vitamin A level, relative dosage reaction and stable-isotope dilution technique. At the same time, their dietary vitamin A intakes were estimated by weighted-food dietary survey. The dietary vitamin A requirement in young children was determined on the basis of dietary vitamin A intakes in Children with adequate vitamin A level.

Condition or disease
Vitamin A Deficiency

Study Design
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Study Type : Observational
Actual Enrollment : 403 participants
Time Perspective: Cross-Sectional
Official Title: Estimating Dietary Vitamin A Requirement in Chinese Children by Stable-isotope Dilution Technique
Study Start Date : July 2009
Actual Primary Completion Date : July 2010
Actual Study Completion Date : September 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Vitamin A
Drug Information available for: Vitamin A

Groups and Cohorts
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Group/Cohort
4-6 years old group
7-9 years old group


Outcome Measures
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Biospecimen Retention:   Samples Without DNA
serum

Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   4 Years to 9 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study was carried out in a kindergarten and an elementary school in Shiyan city, Hubei province of China. Initially, 201 kindergarten children (4-6 years old) and 202 grade children (7-9 years old) were subjected to a questionnaire survey on personal information, medical history and dietary habits including dietary supplements.ongoing or previous illnesses, having taken nutritional supplements within 3 months, positive results in the fat absorption test or parasite test, increased level of CRP (> 8 mg/L), or lower serum level of retinol (<1.40 umol/L), and higher ratio in relative dosage reaction test(>20%) .After the screening, 123 children were selected and completed the study, but 60 subjects were randomly selected for the DRD test to evaluate liver vitamin A storage.
Criteria

Inclusion Criteria:

  • well-nourished children with normal serum retinol(>=1.40umol/L)

Exclusion Criteria:

  • ongoing or previous illnesses,
  • having taken nutritional supplements within 3 months,
  • positive results in the fat absorption test or parasite test,
  • increased level of CRP (> 8 mg/L), or
  • lower serum level of retinol (< 1.40 umol/L)
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01559766


Locations
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China, Hubei
Shiyan Centre for Disease Control and Prevention
Shiyan, Hubei, China, 442500
Sponsors and Collaborators
Huazhong University of Science and Technology
ShiYan Centre for Disease Control and Prevention
Tufts Medical Center
Investigators
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Principal Investigator: Xiufa Sun, BS Tongji Medical College, Huazhong University of Science and Technology
More Information
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Responsible Party: Xiufa Sun, Professor, Huazhong University of Science and Technology
ClinicalTrials.gov Identifier: NCT01559766    
Other Study ID Numbers: No.2008BAI58B03
First Posted: March 21, 2012    Key Record Dates
Last Update Posted: March 21, 2012
Last Verified: March 2012
Keywords provided by Xiufa Sun, Huazhong University of Science and Technology:
Vitamin A
Dietary requirement
Dietary records
Deuterated retinol dilution technique
 Chinese children
Dietary intake of vitamin A
Vitamin A liver reserves
Additional relevant MeSH terms:
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Night Blindness
Vitamin A Deficiency
Avitaminosis
Deficiency Diseases
 Malnutrition
Nutrition Disorders
Vision Disorders
Eye Diseases