Akershus Cardiac Examination (ACE) 1950 Study (ACE1950)

• Sponsor: Vestre Viken Hospital Trust
• Collaborator: University Hospital, Akershus
• Information provided by (Responsible Party): Vestre Viken Hospital Trust

Study Description

Brief Summary:

Akershus Cardiac Examination (ACE) 1950 Study is a large, observational, prospective, longitudinal, population-based cohort study. The overall aim is to establish an extensive cardio- and cerebrovascular age cohort of elderly subjects for various longitudinal long-term follow-up studies of cardiovascular and cerebrovascular disease.

Condition or disease
Atrial Fibrillation; Heart Failure; Mild Cognitive Impairment; Cardiovascular Diseases; Cerebrovascular Disorders

Detailed Description:

Design: The Akershus Cardiac Examination (ACE) 1950 Study is a population-based, prospective, cerebro- and cardiovascular age-cohort study of all men and women born in 1950 in Akershus County, Norway.

Time schedule: Study inclusion and baseline examinations took place in the period September 2012 - May 2015. Follow-up and sub-studies are ongoing.

Current status: As per May 2018, follow-up and sub-studies are ongoing.

Study Design

• Study Type: Observational
• Actual Enrollment: 3706 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects
• Study Start Date: September 2012
• Actual Primary Completion Date: May 2015
• Estimated Study Completion Date: December 2050

Groups and Cohorts

Group/Cohort
No treatment

Outcome Measures

Primary Outcome Measures :

1. Outcomes related to CVD and CV-associated conditions [ Time Frame: Maximum 35 years ]

Secondary Outcome Measures :

1. Specific CV endpoints; e.g. acute myocardial infarction, heart failure, atrial fibrillation, etc. [ Time Frame: Maximum 35 years ]
2. Specific CV-associated conditions, including renal, cerebrovascular, pulmonary, etc. [ Time Frame: Maximum 35 years ]
3. Specific clinical phenotypes; e.g. myocardial and arterial structure and function, lung function, etc. [ Time Frame: Maximum 35 years ]

Other Outcome Measures:

1. Impact of left atrial size and function measurements by echocardiography on stroke risk in an 62-65-year-old cohort [ Time Frame: Within 35 years ]
2. Relation between cognitive function and sub-clinical CVD in a 62-65-year-old Norwegian population cohort [ Time Frame: Maximum 35 years ]

Biospecimen Retention:   Samples With DNA

Blood samples, including for genetic testing, and urine.

Eligibility Criteria

• Ages Eligible for Study: 62 Years to 65 Years (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes
• Sampling Method: Non-Probability Sample

Study Population

Residents of Akershus County, Norway, born in 1950.

Criteria

Inclusion Criteria:

• Resident in Akershus County (as per October 2011, prior to study invitation)
• Born in the year of 1950
• Ability to consent to participation

Contacts and Locations

Locations

Norway

Akershus University Hospital

Lørenskog, Akershus, Norway, 1478

Vestre Viken HT, Baerum Hospital, Department of Medical Research

Sandvika, Akershus, Norway, 3004

Sponsors and Collaborators

Vestre Viken Hospital Trust

University Hospital, Akershus

Investigators

• Study Director: Arnljot Tveit, MD, PhD; Vestre Viken Hospital Trust, Department of Medical Research
• Study Director: Helge Røsjø, MD, PhD; University Hospital, Akershus
• Principal Investigator: Trygve Berge - member of steering committee, MD; Vestre Viken Hospital Trust, Department of Medical Research
• Principal Investigator: Pål Smith - member of steering committee, MD, PhD; University Hospital, Akershus
• Principal Investigator: Kjetil Steine - member of steering committee, MD, PhD; University Hospital, Akershus
• Principal Investigator: Torbjørn Omland - member of steering committee, MD, PhD; University Hospital, Akershus
• Principal Investigator: Magnus N Lyngbakken - member of steering committee, MD; University Hospital, Akershus

More Information

Additional Information:

Study website 

Publications of Results:

Ihle-Hansen H, Vigen T, Berge T, Einvik G, Aarsland D, Rønning OM, Thommessen B, Røsjø H, Tveit A, Ihle-Hansen H. Montreal Cognitive Assessment in a 63- to 65-year-old Norwegian Cohort from the General Population: Data from the Akershus Cardiac Examination 1950 Study. Dement Geriatr Cogn Dis Extra. 2017 Sep 28;7(3):318-327. doi: 10.1159/000480496. eCollection 2017 Sep-Dec.

Berge T, Brynildsen J, Larssen HKN, Onarheim S, Jenssen GR, Ihle-Hansen H, Christophersen IE, Myrstad M, Røsjø H, Smith P, Tveit A. Systematic screening for atrial fibrillation in a 65-year-old population with risk factors for stroke: data from the Akershus Cardiac Examination 1950 study. Europace. 2018 Nov 1;20(FI_3):f299-f305. doi: 10.1093/europace/eux293.

Other Publications:

Berge T, Vigen T, Pervez MO, Ihle-Hansen H, Lyngbakken MN, Omland T, Smith P, Steine K, Røsjø H, Tveit A; ACE 1950 Study Group. Heart and Brain Interactions--the Akershus Cardiac Examination (ACE) 1950 Study Design. Scand Cardiovasc J. 2015;49(6):308-15. doi: 10.3109/14017431.2015.1086813. Epub 2015 Sep 12.

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Berge T, Lyngbakken MN, Ihle-Hansen H, Brynildsen J, Pervez MO, Aagaard EN, Vigen T, Kvisvik B, Christophersen IE, Steine K, Omland T, Smith P, Røsjø H, Tveit A. Prevalence of atrial fibrillation and cardiovascular risk factors in a 63-65 years old general population cohort: the Akershus Cardiac Examination (ACE) 1950 Study. BMJ Open. 2018 Aug 1;8(7):e021704. doi: 10.1136/bmjopen-2018-021704.

Ihle-Hansen H, Vigen T, Ihle-Hansen H, Rønning OM, Berge T, Thommessen B, Lyngbakken MN, Orstad EB, Enger S, Nygård S, Røsjø H, Tveit A. Prevalence of Carotid Plaque in a 63- to 65-Year-Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study. J Am Heart Assoc. 2018 May 8;7(10). pii: e008562. doi: 10.1161/JAHA.118.008562.

• Responsible Party: Vestre Viken Hospital Trust
• ClinicalTrials.gov Identifier: NCT01555411 History of Changes
• Other Study ID Numbers: 2011/1475 C; AFIA (initial study name) ( Other Identifier: Vestre Viken Hospital Trust and Akershus University Hospital )
• First Posted: March 15, 2012
• Last Update Posted: May 7, 2018
• Last Verified: May 2018

Keywords provided by Vestre Viken Hospital Trust:

Cardiovascular epidemiology; Prospective, observational cohort study; Biomarkers; Cardio- and cerebrovascular imaging

Additional relevant MeSH terms:

Heart Failure; Atrial Fibrillation; Cardiovascular Diseases; Cognitive Dysfunction; Cerebrovascular Disorders; Heart Diseases; Arrhythmias, Cardiac; Pathologic Processes; Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases