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Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal (SchistoVAN)

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ClinicalTrials.gov Identifier: NCT01553552
Recruitment Status : Completed
First Posted : March 14, 2012
Last Update Posted : March 14, 2012
Sponsor:
Collaborators:
Institut Pasteur de Lille
University of Lille Nord de France
Région Nord-Pas de Calais, France
Centre d'Infection et d'Immunité de Lille
Centre National de la Recherche Scientifique, France
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by (Responsible Party):
Biomedical Research Center EPLS

Study Description
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Brief Summary:
SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the immune response of children to childhood vaccine antigens, as well as the impact of this infection on their nutritional status and their haemoglobinaemia.

Condition or disease
Schistosomiasis Anemia Underweight Stunting Intestinal Parasites

Detailed Description:

SchistoVAN aims to study the interactions between chronic parasite infections such as schistosomiasis and the immunological and nutritional status of children. In this scope, the investigators conducted a case-control study where one group of children is infected with schistosoma haematobium and the other is not infected with this parasite.

The investigators then stimulated whole blood of these children with various vaccine antigens to address their immune function and study the influence of schistosomiasis infectious state on their overall immune condition.

Aims of the study:

To evaluate the interaction between schistosomiasis and the nutritional status of children and their haemoglobinemia.

To evaluate the influence of schistosomiasis on children's specific immune response towards EPI vaccine antigens, the inflammatory status of children and nutritional serologic markers.

To compare schistosomiasis diagnostic tools (evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in comparison with microscopy and urinary dipsticks)

To study prevalence of intestinal parasites such as Blastocystis hominis

Study Design
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Study Type : Observational
Actual Enrollment : 99 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Comparison of Schistosomiasis Diagnostic Techniques and Study of Schistosoma Infection on Children's Immune Response to Childhood Vaccines, on Anaemia and on Nutritional Status
Study Start Date : October 2011
Actual Primary Completion Date : October 2011
Actual Study Completion Date : October 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Anemia

Groups and Cohorts
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Group/Cohort
Infected by Schistosoma haematobium
Not infected by Schistosoma haematobium


Outcome Measures
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Biospecimen Retention:   Samples Without DNA
Whole blood Sera Urine Stool

Eligibility Criteria
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Ages Eligible for Study:   6 Years to 10 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Residents of 3 villages from the Senegal Valley River, belonging to the Podor District in Saint-Louis Region in Northern Senegal: Agniam Towguel, Fanaye Diery and Niandane. Subcohort of a previous study "AnoPalAnoVac" (ClinicalTrials.gov ID: NCT01545115)
Criteria

Inclusion Criteria:

  • Members of AnoPalAnoVac cohort
  • Age: between 6 and 10 years

Exclusion Criteria:

  • body temperature > 38.5 ºC
  • malaria episode
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01553552


Locations
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Senegal
Biomedical Research Center EPLS
Saint-Louis, SL, Senegal
Sponsors and Collaborators
Biomedical Research Center EPLS
Institut Pasteur de Lille
University of Lille Nord de France
Région Nord-Pas de Calais, France
Centre d'Infection et d'Immunité de Lille
Centre National de la Recherche Scientifique, France
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
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Study Chair: Emmanuel Hermann, PhD A.Pr. Biomedical Research Center EPLS
Study Director: Lobna Gaayeb, VetMed Biomedical Research Center EPLS
Principal Investigator: Modou Seck, MD Biomedical Research Center EPLS
More Information
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Additional Information:

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Biomedical Research Center EPLS
ClinicalTrials.gov Identifier: NCT01553552    
Other Study ID Numbers: EPLS11-MS
First Posted: March 14, 2012    Key Record Dates
Last Update Posted: March 14, 2012
Last Verified: March 2012
Keywords provided by Biomedical Research Center EPLS:
Schistosoma haematobium
schistosoma mansoni
Anemia
 Underweight
stunting
Blastocystis
Additional relevant MeSH terms:
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Schistosomiasis
Intestinal Diseases, Parasitic
Anemia
Growth Disorders
Thinness
Hematologic Diseases
Trematode Infections
 Helminthiasis
Parasitic Diseases
Pathologic Processes
Body Weight
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases