Physical Activity and Basal Metabolic Rate in Postmenopausal Women
|ClinicalTrials.gov Identifier: NCT01550536|
Recruitment Status : Completed
First Posted : March 12, 2012
Last Update Posted : March 12, 2012
|Condition or disease||Intervention/treatment||Phase|
|Postmenopausal Metabolic Health||Behavioral: Resistance and aerobic exercise||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||49 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Aging and Basal Metabolic Rate in Postmenopausal Women: Effects of Long-Term and Short-Term Physical Activity|
|Study Start Date :||January 2008|
|Actual Primary Completion Date :||August 2010|
|Actual Study Completion Date :||August 2010|
Sedentary women who exercised <2 hours per week and who had never engaged in a regular exercise program were enrolled in an exercise training intervention, following baseline measurements. See intervention below.
Behavioral: Resistance and aerobic exercise
Following baseline measurements, sedentary women were enrolled in a 16-week exercise training program at the YMCA in La Jolla, CA. Exercise occurred 3 times per week, for 1.5 hours each time. Exercise consisted of stretching, 20 minutes of aerobic exercise on elliptical machines, and 3 sets of 10-12 repetitions to failure for each of ten weight lifting exercises: abdominal crunch, arm curl, arm extension, chest press, lat pull-down, leg curl, leg extension, leg press, seated row, and trunk extension. Women started at 65-75% of 1-repetition-maximum, and resistance was increased as necessary to maintain the number of sets and reps and to continue to work to failure. Exercise was monitored by a TechnoGym electronic key system, and trainers instructed and supervised subjects in the gym.
No Intervention: Active
Postmenopausal women who exercised >5 hours per week and had been doing so for at least the past 10 years. These women were asked to maintain their normal activity habits for the duration of the study.
- Change in basal metabolic rate [ Time Frame: baseline, 5, 10 and 16 weeks ]Basal metabolic rate is the energy expended at rest and under fasting conditions.
- Change in fat-free mass [ Time Frame: baseline, 5, 10 and 16 weeks ]
- Change in maximal aerobic capacity [ Time Frame: baseline, 16 weeks ]The maximal oxygen consumption achieved during a graded exercise test to exhaustion. Equipment: electronically-braked cycle ergometer. Participants were screened for CVD risk prior to testing by a physician. Lead II EKG was monitored during testing, and each test was overseen by a physician.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01550536
|United States, California|
|La Jolla YMCA|
|La Jolla, California, United States, 92037|
|UCSD Human Exercise Physiology Laboratory|
|La Jolla, California, United States, 92093-0623|
|UCSD General Clinical Research Center|
|San Diego, California, United States, 92093-0990|
|Principal Investigator:||Andrew W Froehle, PhD||University of California, San Diego|