Typical Daily Experiences, Ischemia and Repolarization in Coronary Artery Disease
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|ClinicalTrials.gov Identifier: NCT01531231|
Recruitment Status : Unknown
Verified July 2013 by Richard Lane, University of Arizona.
Recruitment status was: Recruiting
First Posted : February 10, 2012
Last Update Posted : July 24, 2013
|Condition or disease|
|Coronary Artery Disease Behavioral|
CAD is the most common setting in which sudden cardiac death (SCD) occurs. SCD is the leading cause of death in the U.S.
In this study we propose to test the following in patients with CAD:
- Determine whether experiences assessed randomly throughout the day are associated with changes in the blood supply to your heart muscle as measured by electrical recordings from your chest.
- Determine whether typical daily experiences are associated with changes in the recovery time portion of your heart beat cycle as measured by electrical recordings from your chest.
- Determine whether changes in the recovery time portion of your heart beat cycle associated with typical daily experiences occur exclusively with changes in the blood supply to your heart muscle.
- Determine whether typical daily experiences influences blood supply and recovery time based on the severity and presence of CAD (when comparing CAD patients to healthy subjects).
|Study Type :||Observational|
|Estimated Enrollment :||300 participants|
|Official Title:||Typical Daily Emotions, Ischemia and Repolarization in Coronary Artery Disease|
|Study Start Date :||January 2012|
|Estimated Primary Completion Date :||January 2015|
|Estimated Study Completion Date :||February 2015|
YOUNGER HEALTHY NO CORONARY ARTERY DISEASE (CAD)
- Whether an association between typical daily experiences and recovery time varies with age; this group will be compared to the older comparison group and to previous data collected from those subjects who participated in the Long QT Syndrome study (LQTS).
OLDER HEALTHY SUBJECTS NO CORONARY ARTERY DISEASE (CAD)
- Determine whether daily emotion influences ischemia and repolarization differentially as a function of the severity of CAD and presence of CAD when comparing CAD patients with healthy patients
HIGH RISK CORONARY ARTERY DISEASE (CAD)
- Determine whether emotion assessed randomly throughout the day is associated with myocardial ischemia
LOW RISK CORONARY ARTERY DISEASE (CAD)
- Determine whether typical daily emotion influences ischemia and repolarization differentially as a function of the severity of CAD and presence of CAD
- To obtain behavioral and cardiovascular data including 4-days collection of data as study participant engages in their daily activities. [ Time Frame: 4 days ]To determine whether typical daily emotion is associated with myocardial ischemia and repolarization changes in patients with coronary artery disease, and then determine whether the association between repolarization changes and daily emotion is related to myocardial ischemia; whether daily emotion influences ischemia and repolarization differentially as a function of severity of coronary artery disease; whether the association between daily emotion and repolarization varies in healthy volunteers. Some of these outcomes are intertwined.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01531231
|Contact: Marcia R Webster, BA, CCRCfirstname.lastname@example.org|
|Contact: Sarah Sharp, BSemail@example.com|
|United States, Arizona|
|University of Arizona||Recruiting|
|Tucson, Arizona, United States, 85724|
|Principal Investigator:||Richard D Lane, MD, PhD||University of Arizona|