Effect of a Component of Fish Oil on Exercise-Induced Bronchoconstriction and Airway Inflammation in Asthma
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|ClinicalTrials.gov Identifier: NCT01504646|
Recruitment Status : Completed
First Posted : January 5, 2012
Last Update Posted : October 23, 2018
|Condition or disease||Intervention/treatment||Phase|
|Asthma Exercise-Induced Bronchoconstriction||Dietary Supplement: Lyprinol Dietary Supplement: Placebo (Olive Oil)||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Randomized Controlled Trial of Marine Lipid Fraction PCSO-524™ on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction in Asthma|
|Study Start Date :||January 2012|
|Actual Primary Completion Date :||August 2012|
|Actual Study Completion Date :||August 2012|
Placebo Comparator: Olive Oil Capsule
Ten subjects will take eight placebo olive oil capsules per day for three weeks.
Dietary Supplement: Placebo (Olive Oil)
8 capsules (1 capsule = 100mg olive oil) per day for 3 weeks
Other Name: Olive Oil
Ten subjects will take eight Lyprinol capsules per day for three weeks.
Dietary Supplement: Lyprinol
8 capsules (1 capsule=50mg n-PUFA, 100mg olive oil) per day for 3 weeks
- Pulmonary Function (Percent Change in FEV1, measured in Liters) [ Time Frame: 8 weeks ]The percent change in FEV1 is the percent change in the volume of air exhaled during the first second of a forced exhalation as measured before and after the surrogate exercise challenge.
- Fraction of Exhaled Nitric Oxide [ Time Frame: 8 weeks ]The concentration of exhaled Nitric Oxide (measured as parts per billion) will be measured using a Nitric Oxide Analyzer.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01504646
|United States, Indiana|
|Indiana University School of Health, Physical Education, and Recreation|
|Bloomington, Indiana, United States, 47405|