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Association Between cd163 Gene Polymorphisms and Sepsis Among Chinese Han Population

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01504243
Recruitment Status : Unknown
Verified December 2011 by Chinese PLA General Hospital.
Recruitment status was:  Recruiting
First Posted : January 5, 2012
Last Update Posted : January 5, 2012
Information provided by:
Chinese PLA General Hospital

Brief Summary:
CD163 is a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage.CD163 acts to amplify inflammation and serves as a critical mediator of inflammatory response in the context of sepsis. This study was designed to investigate whether CD163 genomic variations were associated with the prognosis of sepsis. We sequenced 30 sepsis patients with CD163 gene of seventeen exons by PCR sequencing. When analyzing the results of sequencing, we found five gene polymorphisms located in exon-2,exon-5 and exon-11, respectively. Compare with the NCBI dbSNP and Hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs3210140, two polymorphisms located in exon-5 are synonymous variations rs4883264 and rs4883263, the last two located in exon-11 are synonymous variations rs61729512 and rs150018775 . Five common polymorphisms (rs2234237,rs2234246) within the CD163 gene were detected in 200 patients with severe sepsis and in 200 healthy control subjects. This study was explored that whether or not polymorphisms detected within the CD163 gene may play a major role in the predisposition to prognosis of sepsis in a Chinese Han cohort.

Condition or disease

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Study Type : Observational
Estimated Enrollment : 400 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Association Between cd163 Gene Polymorphisms and Sepsis Among Chinese Han Population
Study Start Date : May 2010
Estimated Primary Completion Date : May 2012
Estimated Study Completion Date : May 2012

Resource links provided by the National Library of Medicine

normal person under medical examination
SIRS plus inflammation

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
All subjects were selected from among inpatients who were hospitalized between September 2009 and October 2011 in the Respiratory ICU, Surgical ICU, and Emergency ICU, Chinese People's Liberation Army (CPLA) General Hospital.

Inclusion Criteria:

  • Sepsis met the criteria recommended by 1991 ACCP/SCCM Joint Meeting and by the diagnostic criteria developed at the 2001 International Sepsis Definition Conference.

Exclusion Criteria:

  • (1) younger than 18 years of age; (2) acquired immunodeficiency syndrome; (3) reduced polymorphonuclear granulocyte counts (< 500 μL-1); (4) died within 24h after admission into the ICU, or refused to participate in the study, or declined treatment during the period of observation.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01504243

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Contact: Zhao xv Jiang, Ms +86 15010540218

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China, Beijing
Chinese PLA General Hospital Recruiting
Beijing, Beijing, China
Sponsors and Collaborators
Chinese PLA General Hospital
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Study Director: Li xin Xie, MD Respiratory Disease Department of chinese PLA General Hospital
Layout table for additonal information Identifier: NCT01504243    
Other Study ID Numbers: 20111013-009(1)
2009BAI86B03 ( Other Grant/Funding Number: Chinese National Science & Technology Pillar Program )
First Posted: January 5, 2012    Key Record Dates
Last Update Posted: January 5, 2012
Last Verified: December 2011
Keywords provided by Chinese PLA General Hospital:
control(normal person)
Additional relevant MeSH terms:
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Systemic Inflammatory Response Syndrome
Pathologic Processes