Genome-wide Association Study

This study has been withdrawn prior to enrollment.
(Registration poor)
Information provided by (Responsible Party):
Jeeyun Lee, Samsung Medical Center Identifier:
First received: December 21, 2011
Last updated: December 28, 2015
Last verified: December 2015
To explore biomarkers predictive of clinical response to Taxane/5-FU/platinum based chemotherapy in esophageal squamous cell carcinoma. To identify negative predictive markers to 5-FU/platinum/Taxane. To elucidate signal transduction pathway attributable to 5-FU/platinum/Taxane resistance. To analyze correlation between the quantity of circulating tumor cells and circulating endothelial cell precursors and treatment response to Taxane/5-FU/platinum based chemotherapy.

Esophageal Squamous Cell Carcinoma.

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Genome-wide Association Study to Predict Treatment Response for Chemotherapy in Esophageal Squamous Cell Carcinoma

Resource links provided by NLM:

Further study details as provided by Samsung Medical Center:

Primary Outcome Measures:
  • Biomarkers predictive [ Time Frame: 24months ] [ Designated as safety issue: No ]
    Biomarkers predictive of clinical response to Taxane or 5-fluorouracil or platinum based chemotherapy.

Enrollment: 0
Study Start Date: January 2012
Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Patients treated with Taxane/5-FU/platinum based chemo.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Esophageal squamous cell carcinoma Patients treated with Taxane/5-FU/platinum based chemotherapy.

Inclusion Criteria:

  • Histological confirmed esophageal squamous cell carcinoma
  • Patients treated with Taxane or 5-FU or platinum based chemotherapy.
  • provision of a signed written informed consent.

Exclusion Criteria:

  • patients not signed written informed consent.
  • patient unacceptable for study in the judgement of the investigator.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01498757

Korea, Republic of
Samsung medical Center
Seoul, Korea, Republic of
Sponsors and Collaborators
Samsung Medical Center
  More Information

Responsible Party: Jeeyun Lee, Professor of Medicine, Sungkyunkwan University School of Medicine, Department of Hematology and Oncology, Samsung Medical Center Identifier: NCT01498757     History of Changes
Other Study ID Numbers: 2011-05-076 
Study First Received: December 21, 2011
Last Updated: December 28, 2015
Health Authority: Korea: Food and Drug Administration

Additional relevant MeSH terms:
Carcinoma, Squamous Cell
Esophageal Neoplasms
Digestive System Diseases
Digestive System Neoplasms
Esophageal Diseases
Gastrointestinal Diseases
Gastrointestinal Neoplasms
Head and Neck Neoplasms
Neoplasms by Histologic Type
Neoplasms by Site
Neoplasms, Glandular and Epithelial
Neoplasms, Squamous Cell processed this record on May 26, 2016