Anesthesia and Lymphocytes Apoptosis (OPCAB)
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ClinicalTrials.gov Identifier: NCT01461551 |
Recruitment Status :
Completed
First Posted : October 28, 2011
Results First Posted : November 20, 2014
Last Update Posted : May 22, 2015
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Anesthesia | Drug: Sevoflurane Drug: Propofol Drug: combine of sevoflurane and propofol | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 105 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Single (Participant) |
Primary Purpose: | Prevention |
Official Title: | Different Effects of Sevoflurane, Propofol and Combine of Sevoflurane and Propofol Maintained Anesthesia on Peripheral Blood Lymphocytes During Off-pump Coronary Artery Bypass Graft Surgery |
Study Start Date : | October 2011 |
Actual Primary Completion Date : | February 2012 |
Actual Study Completion Date : | October 2014 |

Arm | Intervention/treatment |
---|---|
Experimental: Sevoflurane |
Drug: Sevoflurane
anesthesia was maintained with sevoflurane (end-tidal concentration 1.0-1.5 minimum alveolar concentration) |
Experimental: Propofol |
Drug: Propofol
anesthesia was maintained with propofol (2-4 μg/ml via target-controlled infusion) |
Experimental: Combine of sevoflurane and propofol |
Drug: combine of sevoflurane and propofol
anesthesia was maintained with a combine of propofol (1 μg/ml via target-controlled infusion) and sevoflurane (end-tidal concentration 0.7-1.0 minimum alveolar concentration) |
- Lymphocyte Count [ Time Frame: 1 day after surgery ]Blood samples were obtained 24 h after the surgery for routine blood examination. This analysis was performed in the hospital laboratory using routine laboratory procedures.
- Intensive Care Unit Staying Days [ Time Frame: participants will stay in intensive care unit after surgery, an expected average of 2 days ]

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Ages Eligible for Study: | 18 Years to 80 Years (Adult, Older Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- male adults
- aged 18-80 yr
- undergoing elective OPCAB surgery containing left anterior descending artery bypass
Exclusion Criteria:
- a previous unusual response to any of the experimental anesthetics
- severe cardiac dysrhythmias or ejection fraction below 30%
- hemodynamic instability
- previous surgical coronary artery repair
- anemia, abnormal leukocytes or coagulopathy
- severe hypertension
- severe hepatic (albumin<30g,ascites), renal (serum creatinine greater than 2.0 mg/dl) or pulmonary (preoperative pulmonary function tests moderate-severe) dysfunctions
- concomitant surgical procedures and psychiatric disorders
- Insulin-dependent diabetics

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01461551
China, Shanghai | |
Ruijin Hospital | |
Shanghai, Shanghai, China, 200025 |
Study Director: | Bu-Wei Yu, Ph.D., M.D. | Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao tong University School of Medicine |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Li-Jie Jia, resident, Ruijin Hospital |
ClinicalTrials.gov Identifier: | NCT01461551 |
Other Study ID Numbers: |
OPCAB |
First Posted: | October 28, 2011 Key Record Dates |
Results First Posted: | November 20, 2014 |
Last Update Posted: | May 22, 2015 |
Last Verified: | May 2015 |
troponin I creatine kinase mb hospital days lymphocyte apoptosis intensive care unit days |
Propofol Sevoflurane Hypnotics and Sedatives Central Nervous System Depressants Physiological Effects of Drugs |
Anesthetics, Intravenous Anesthetics, General Anesthetics Platelet Aggregation Inhibitors Anesthetics, Inhalation |