Effects of Lubiprostone on Gastric Function in Patients With Chronic Idiopathic Constipation
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ClinicalTrials.gov Identifier: NCT01460225 |
Recruitment Status :
Completed
First Posted : October 26, 2011
Results First Posted : July 13, 2018
Last Update Posted : July 13, 2018
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Chronic Idiopathic Constipation | Drug: lubiprostone | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 19 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Health Services Research |
Official Title: | Effects of Lubiprostone on Gastric Sensory and Motor Function in Patients With Chronic Idiopathic Constipation |
Study Start Date : | September 2007 |
Actual Primary Completion Date : | December 2010 |
Actual Study Completion Date : | January 2011 |

Arm | Intervention/treatment |
---|---|
Experimental: Treatment
24 micrograms of lubiprostone twice daily for one week.
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Drug: lubiprostone
24 micrograms twice daily for 1 week |
- Gastric Emptying [ Time Frame: Day 1 and Day 7 ]gastric emptying was measured before and after 7 days of treatment.at set times (2 and 4 hours post eating a radio-labeled meal)

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- chronic idiopathic constipation
Exclusion Criteria:
- medications that slow gastrointestinal (GI) motility
- prior surgery to the GI tract

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01460225
United States, New Hampshire | |
Dartmouth-Hitchcock Medical Center | |
Lebanon, New Hampshire, United States, 03756 |
Responsible Party: | Dartmouth-Hitchcock Medical Center |
ClinicalTrials.gov Identifier: | NCT01460225 |
Other Study ID Numbers: |
07-033L |
First Posted: | October 26, 2011 Key Record Dates |
Results First Posted: | July 13, 2018 |
Last Update Posted: | July 13, 2018 |
Last Verified: | July 2018 |
constipation chronic idiopathic constipation no prior history of surgery to the colon not on any type of medication that could alter gastrointestinal motility or transit |
Constipation Signs and Symptoms, Digestive Lubiprostone |
Chloride Channel Agonists Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action |