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Gastric Cancer Metastasized to the Central Nervous System (CNS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT01456455
Recruitment Status : Active, not recruiting
First Posted : October 20, 2011
Last Update Posted : October 25, 2016
Sponsor:
Information provided by (Responsible Party):
University of Zurich

Brief Summary:

Descriptive registry to investigate frequency of HER-2 positive gastric cancer involving CNS.

Exploration of additional prognostic factors for brain involvement from gastric cancer.


Condition or disease
Gastric Cancer

Detailed Description:
HER2 Status E-Cadherin Status

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Study Type : Observational [Patient Registry]
Actual Enrollment : 150 participants
Observational Model: Cohort
Target Follow-Up Duration: 2 Years
Official Title: Registry of Gastric Cancer and Brain Metastases
Study Start Date : August 2011
Estimated Primary Completion Date : March 2020
Estimated Study Completion Date : August 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Stomach Cancer




Primary Outcome Measures :
  1. HER2 Status [ Time Frame: 2 years ]
    Determination of HER2 Status on Tumor Tissue


Secondary Outcome Measures :
  1. Outcome according to HER2 Status [ Time Frame: 2 years ]

Other Outcome Measures:
  1. Outcome according to ethnicity of patients [ Time Frame: 2 years ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
international
Criteria

Inclusion criteria:

  • in order to be eligible for the study, the diagnosis of gastric cancer and/or lower esophageal cancer must be confirmed histologically. CNS involvement must be confirmed either via independent neuroradiological and/or positive CSF cytology.

Exclusion criteria:

  • Patients whose diagnosis is not confirmed upon pathological review or where the CNS involvement cannot be confirmed after neuroradiological review will be excluded from this study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01456455


Locations
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Switzerland
Dept Oncology, University Hospital Zürich
Zurich, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Investigators
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Study Director: 01 Studienregister MasterAdmins UniversitaetsSpital Zuerich
Principal Investigator: Silvia Hofer, MD University Hospital Zurich, Division of Oncology

Additional Information:

Publications of Results:
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Responsible Party: University of Zurich
ClinicalTrials.gov Identifier: NCT01456455    
Other Study ID Numbers: UGICNS
First Posted: October 20, 2011    Key Record Dates
Last Update Posted: October 25, 2016
Last Verified: October 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by University of Zurich:
Central nervous system
pathological markers
Additional relevant MeSH terms:
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Stomach Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Stomach Diseases