Prevalence of Dry Eyes in Diabetics Compared to Non Diabetics
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ClinicalTrials.gov Identifier: NCT01450787
Recruitment Status :
(Principle investigator changed practice location and discontinued study)
The purpose is to compare the prevalence of dry eyes in diabetics and non diabetics. This might help identify a group of patients at greater risk for dry eye complications. Diabetics have been shown to have poor ocular surface healing and might benefit from dry eye therapy earlier if they are shown to be at greater risk for dry eyes.
Condition or disease
Dry eye disease is one of the most common eye problems seen in ophthalmology. Diabetics are at high risk for multiple eye problems, including retinopathy and glaucoma. They also have been shown to have poor ocular surface healing. I would like to evaluate the prevalence of dry eye disease in diabetics to see if they are also at greater risk for the known complications of dry eye disease. If so, they might benefit from early intervention.
Conjunctival Staining Score [ Time Frame: at the time of the evaluation ]
Conjunctival staining with lissamine green dye is measured at the time of the evaluation on a scale from 0 to 5 using the oxford scoring system, with 5 being the most severe staining.
Secondary Outcome Measures :
Tear Film Osmolarity [ Time Frame: at the time of the exam ]
The tear film osmolarity is measured at the time of the exam.
Other Outcome Measures:
OSDI Score [ Time Frame: at the time of the exam ]
The ocular surface disease index survey in completed at the time of the exam. This scale ranges from 0 to 100 higher scores representing greater disability.
Schirmer Score [ Time Frame: at the time of the exam ]
The schirmer tear production test with anesthesia is completed at the time of the exam in mm of tear film absorption on the test strip after five minutes. Higher scores represent greater tear production.
Tear Break-up Time [ Time Frame: at the time of the exam ]
The tear break-up time with fluorescein solution is measured at the time of the exam in seconds.
Corneal Staining [ Time Frame: at the time of the exam ]
Corneal staining with fluorescein solution is graded at the time of the exam on a scale of 0 to 5 using the oxford scoring system with 5 being the most severe staining.
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Layout table for eligibility information
Ages Eligible for Study:
40 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Existing clinic population from our practice
50 patients with diabetes, 25 without diabetes over the age of 40
current use of glaucoma drops or currently within the postoperative period from eye surgery