Non-Invasive Imaging of Atherosclerosis
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|ClinicalTrials.gov Identifier: NCT01418313|
Recruitment Status : Completed
First Posted : August 17, 2011
Last Update Posted : August 3, 2020
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||886 participants|
|Official Title:||In Vivo Molecular Imaging (MRI) of Atherothrombotic Lesions|
|Study Start Date :||September 2011|
|Actual Primary Completion Date :||March 9, 2020|
|Actual Study Completion Date :||March 9, 2020|
Magnetic resonance imaging (MRI) with and without FDA approved contrast agents: MRI is a non invasive imaging technique used to visualize the internal structure of the body in detail. The MRI machine is an oversized magnet that is always on. It will be used in this study to provide anatomical and functional (MRI with contrast) information about atherosclerotic plaques.
PET/CT and PET/MR
Positron emission tomography (PET)/ computer tomography (CT): PET is a nuclear medicine imaging technique, which produces images of functional processes in the body. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on a biologically active molecule. Nowadays PET imaging is most useful in combination with anatomical imaging, such as CT scanners, thereby PET scanners are now available with integrated high-end multi-detector row CT scanners. Because the two scans can be performed in immediate sequence during the same session and with the patient not changing position between the two scans, areas of abnormality on PET images can be directly correlated with anatomy on the CT images.
Positron emission tomography (PET)/MRI: PET is a nuclear medicine imaging technique, which produces images of functional processes in the body. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on a biologically active molecule. To avoid the additional radiation deriving from the CT scan during PET/CT imaging, nowadays PET imaging can be paired with MR anatomical images.
- Correlation between imaging and biomarkers of atherosclerosis [ Time Frame: 5 years ]R correlation coefficient
- DCE-MRI kinetic parameters [ Time Frame: 3 years ]Parameters evaluating the uptake of MR contrast agent in atherosclerotic plaques. Kinetic parameters Ktrans (1/min) , ve (a.u.), vp (a.u.), Kep (1/min)
- FDG uptake parameters [ Time Frame: 3 years ]Parameters evaluating the uptake of FDG in atherosclerotic plaques. Standardized uptake value (SUV) (a.u.); target to background ratio (TBR) (a.u.)
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01418313
|United States, New York|
|Icahn School of Medicine at Mount Sinai|
|New York, New York, United States, 10029|
|Principal Investigator:||Zahi A Fayad, PhD||Icahn School of Medicine at Mount Sinai|