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Changes in the Permeability of the Blood Brain Barrier and Intestinal Barrier in Humans During Conditions of Stress and Immune Activation: in Vivo Studies

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01417416
Recruitment Status : Completed
First Posted : August 16, 2011
Last Update Posted : August 16, 2011
Information provided by:
National University Hospital, Singapore

Brief Summary:
The relevance of BBB and IB permeability changes as a major precipitating cause for cognitive and digestive dysfunction in the military stress setting.

Condition or disease
Combat Training Stress

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Study Type : Observational
Observational Model: Cohort
Time Perspective: Prospective

with combat training stress
without combat training stress

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Sampling Method:   Probability Sample
Study Population
Healthy male troops during combat training

Inclusion Criteria:

  • Healthy male troops (aged 18-50 yrs) scheduled to be engaged in a protracted multi-day stressful field exercises.

Exclusion Criteria:

  • Significantly systemic disease, including cardiovascular, psychiatric, neurological (including polyneuropathies) and endocrine disease including diabetes mellitus.
  • No written informed consent obtained from subject.
Layout table for additonal information Identifier: NCT01417416    
Other Study ID Numbers: C/08/236
DSOCL08210 ( Other Grant/Funding Number: DSTA Singapore )
First Posted: August 16, 2011    Key Record Dates
Last Update Posted: August 16, 2011
Last Verified: February 2009