Evaluation of Subclinical COronary Atherosclerosis for Risk Stratification Using Coronary Computed Tomography (CT) Angiography (ESCORT)
|ClinicalTrials.gov Identifier: NCT01416532|
Recruitment Status : Unknown
Verified July 2011 by Seoul National University Bundang Hospital.
Recruitment status was: Recruiting
First Posted : August 15, 2011
Last Update Posted : August 18, 2011
|Condition or disease|
The risk stratification of cardiovascular disease (CVD) in asymptomatic individuals represents a major challenge. For this purpose, a lot of risk prediction models that take demographic and clinical characteristics into account have been developed. Although Framingham risk score (FRS) is most widely used among multiplr risk prediction models, it has some limitation for prediction of CVD especially in young adult and women. Recently, coronary artery calcium score (CACS) has known to be powerful screening method for CVD, however, it cannot detect the noncalcified coronary plaques (NCP), so it does not represent the entire spectrum of atherosclerotic plaques and it also cannot evaluate the degree of stenosis. On the contrary, Coronary CT angiography (CCTA)can provide detailed coronary artery anatomy and plaque imaging about the location, burden and characteristics of atherosclerotic plaque per se, which might give additional insight to stratify the risk of future cardiac events and therapy.
In this study, we will evaluate the prevalence and characteristics of subclinical coronary atherosclerosis on CCTA in asymptomatic population. And we will investiage the follow up data for major cardiac adverse event such as cardiac death, nonfatal myocardial infarction, unstable angina and revascularization. Therefore, we will finally evaluate the prognostic value of CCTA for risk stratification in asymptomatic adults in comparsion with conventional risk stratification such as FRS and CACS.
|Study Type :||Observational|
|Estimated Enrollment :||5000 participants|
|Official Title:||Prognostic Value of Coronary CT Angiography in Relation to Evaluation of Subclinical Coronary Atherosclerosis for Risk Stratification in Asymptomatic Individuals From ESCORT Study|
|Study Start Date :||January 2006|
|Actual Primary Completion Date :||December 2007|
|Estimated Study Completion Date :||December 2015|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01416532
|Korea, Republic of|
|Seound National University Bundang Hospital||Recruiting|
|Seongnam-si, Gyeonggi-do, Korea, Republic of, 436-707|
|Contact: Eun Ju Chun, MD, PhD 82-31-787-7618 firstname.lastname@example.org|
|Principal Investigator: Eun Ju Chun, MD, PhD|
|Sub-Investigator: Sang Il Choi, MD, PhD|
|Study Director:||Eun Ju Chun, MD, PhD||Seoul National University Bundang Hospital|