Protein Expression in Human Neuroblastoma Tumor Samples
|ClinicalTrials.gov Identifier: NCT01407731|
Recruitment Status : Completed
First Posted : August 2, 2011
Last Update Posted : May 17, 2016
RATIONALE: Studying protein expression in samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat neuroblastoma.
PURPOSE: This laboratory studying is looking at protein expression in tumor tissue samples from patients with neuroblastoma.
|Condition or disease||Intervention/treatment|
|Neuroblastoma||Genetic: protein expression analysis Genetic: western blotting Other: laboratory biomarker analysis|
- To determine whether intersectin (ITSN1) proteins are present at elevated levels in primary human tumor samples.
OUTLINE: Archived tumor tissue samples are analyzed for intersectin (ITSN1) expression by western blot assays with enhanced chemiluminescence and exposed to X-ray film. The films are scanned, and levels of ITSN1 signal are quantified by densitometry.
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Official Title:||Analysis of Intersectin Expression in Primary Human Neuroblastomas|
|Study Start Date :||July 2011|
|Actual Primary Completion Date :||May 2016|
|Actual Study Completion Date :||May 2016|
- ITSN1 is highly expressed in neuroblastoma tumors and plays an important role in the development/progression of these tumors
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01407731
|Principal Investigator:||John P. O'Bryan, PhD||University of Illinois at Chicago|