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Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01403467
Recruitment Status : Completed
First Posted : July 27, 2011
Last Update Posted : July 27, 2011
Information provided by:
Ramathibodi Hospital

Brief Summary:
This current study aimed to demonstrate the effectiveness of the addition of CPAP to the current conventional therapy in terms of airway obstruction improvement in acute asthma patients.

Condition or disease Intervention/treatment Phase
Acute Asthma Device: Continuous positive airway pressure Phase 4

Detailed Description:
Continuous positive airway pressure (CPAP) is widely used in providing ventilator support. However, its role in an acute asthmatic attack is uncertain. The purpose of this study was to compare the efficacy of CPAP when used in addition to conventional therapy with conventional therapy alone in the management of acute asthma exacerbation.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 86 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation
Study Start Date : April 2009
Actual Primary Completion Date : January 2010
Actual Study Completion Date : January 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma

Arm Intervention/treatment
Experimental: NIPPV Device: Continuous positive airway pressure
CPAP 8 cmH2O
Other Name: GoodKnight 420 G; Nellcor Puritan Bennett Inc.

Primary Outcome Measures :
  1. an improvement in PEFR, as % predicted [ Time Frame: 75 mins ]

Information from the National Library of Medicine

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Ages Eligible for Study:   19 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • aged over 18 years
  • known asthmatic patients visiting ED with acute exacerbation
  • had given their written informed consent.

Exclusion Criteria:

  • smoking history
  • chronic obstructive pulmonary disease
  • required intubation
  • instability of hemodynamic or arrhythmia
  • unable to perform PEFR
  • facial abnormality
  • pulmonary infiltration
  • pregnancy.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01403467

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Ramathibodi Hospital
Bangkok, Thailand, 10400
Sponsors and Collaborators
Ramathibodi Hospital
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Principal Investigator: Yuda Sutherasan, M.D. Ramathibodi Hospital, Mahidol University
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Responsible Party: Dr.Yuda Sutherasan, Ramathibodi Hospital Identifier: NCT01403467    
Other Study ID Numbers: 02-52-28
MURA2009/1239 ( Other Identifier: Ramathibodi Hospital )
First Posted: July 27, 2011    Key Record Dates
Last Update Posted: July 27, 2011
Last Verified: December 2010
Keywords provided by Ramathibodi Hospital:
Bronchial disease
continuous positive airway pressure (CPAP)
Additional relevant MeSH terms:
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Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases