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The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01384136
Recruitment Status : Unknown
Verified June 2011 by Meir Medical Center.
Recruitment status was:  Active, not recruiting
First Posted : June 28, 2011
Last Update Posted : June 28, 2011
Information provided by:
Meir Medical Center

Brief Summary:

The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress.

The investigators aim is to study the telomere system in cord blood and in the placenta immediately after the delivery in pregnancies defined as high risk pregnancies following sterss events such as placental insufficiency, preeclampsia, diabetes.

The investigators intend to compare the telomere system in maternal blood to cord blood and to placental biopsies and to study the influence of different stressogenes on this system.

Condition or disease
Telomere Length Mechanisms of Telomter Homeostasis High Risk Pregnancies

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies
Study Start Date : June 2011
Estimated Primary Completion Date : June 2015
Estimated Study Completion Date : June 2015

High risk pregnancy
|Control - Normal low risk pregnancies

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
High risk pregnancies, third trimester, after the delivery/

Inclusion Criteria:

  • Third trimester post delivery
  • Intrauterine growth restriction
  • Preeclampsia
  • Diabetes
  • Control - low risk normal pregnancies

Exclusion Criteria:

  • Patients who do not want to participate
  • Known HIV or Hepatitis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01384136

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Meir Medical Center
Kfar Saba, Israel
Sponsors and Collaborators
Meir Medical Center
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Responsible Party: Tal Biron-Shental, Meir Medical Center, Kfar Saba, Israel Identifier: NCT01384136    
Other Study ID Numbers: 036-2011 MMC
First Posted: June 28, 2011    Key Record Dates
Last Update Posted: June 28, 2011
Last Verified: June 2011