Microcirculation in Continuous Venovenous Hemofiltration Patients on the Intensive Care Unit
|ClinicalTrials.gov Identifier: NCT01362088|
Recruitment Status : Completed
First Posted : May 27, 2011
Last Update Posted : November 1, 2012
|Condition or disease|
|Continuous Venovenous Hemofiltration|
Before deciding to threat a patient actively with CVVH, a target balance will be agreed for the next 12 hours. Then the ultrafiltration rate for the zero balance is calculated. From there, the ultrafiltration rate progressively increased to 50 ml per hour, up to a maximum ultrafiltration rate of 300 ml per hour.
After each increase of the ultrafiltration rate, the sublingual microcirculation is assessed by SDF.
After obtaining the desired ultrafiltration rate, the microcirculation will again be assessed before and after the patient is temporarily placed in Trendelenburg position. This could possibly show that underfill has the greatest influence on the microcirculation, and not other factors like a rising hematocrit.
|Study Type :||Observational|
|Actual Enrollment :||14 participants|
|Official Title:||Evaluation of Sublingual Microcirculation by Means of SDF Imaging by Stepwise Ultrafiltration in CVVH Patients on the ICU|
|Study Start Date :||September 2011|
|Actual Primary Completion Date :||October 2012|
|Actual Study Completion Date :||October 2012|
- Difference in MFI between zero balance and maximal ultrafiltrationrate (300 ml/hr) [ Time Frame: 4 hours ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01362088
|Medical Centre Leeuwarden|
|Leeuwarden, Netherlands, 8934 AD|
|Principal Investigator:||Christiaan Boerma, MD||Medical Centre Leeuwarden|