Fatigability of the Quadriceps Muscle in Non-cooperating Subjects
|ClinicalTrials.gov Identifier: NCT01345461|
Recruitment Status : Completed
First Posted : May 2, 2011
Last Update Posted : September 29, 2017
|Condition or disease||Intervention/treatment|
|Muscle; Fatigue Heart||Device: transcutaneous electrical muscle stimulation, (model DS7A, Digitimer, Welwyn, Garden City, Hertfordshire, UK)|
|Study Type :||Observational|
|Actual Enrollment :||12 participants|
|Official Title:||Fatigability of the Quadriceps Muscle in Non-cooperating Subjects|
|Actual Study Start Date :||January 2010|
|Actual Primary Completion Date :||May 2011|
|Actual Study Completion Date :||June 2011|
Healthy adult volunteers
Twelve healthy adult volunteers (6 men, 6 women)
Device: transcutaneous electrical muscle stimulation, (model DS7A, Digitimer, Welwyn, Garden City, Hertfordshire, UK)
two constant current high voltage stimulators delivered ten single stimuli twitches with biphasic square pulses at widths of 300 μs. A train generator was then switched on, triggering the delivery a 35 Hz current in bouts of 3 seconds periods separated by 1-second pause for a total of 40 tetanic contractions. In immediate succession to the tetanic contractions a second series of ten single twitch stimuli ended the protocol.
Other Name: Health young subjects
- Fatigue Index (ratio) [ Time Frame: One week ]The tetanic stimulation period was subdivided into five intervals. For each interval the resistance to muscle fatigue was expressed as a Fatigue Index (FI) and calculated as the ratio between the sum of peak torque values from the final three contractions relative to the sum of peak torque values from the first three contractions.
- Slope of regression line (Nm/s) [ Time Frame: One week ]Peak torque values for each contraction were plotted and the slope of the regression line for each interval calculated.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01345461
|Dept. of intensive care 4131, Rigshospitalet, Copenhagen University Hospital|
|Copenhagen, Denmark, DK-2100 OE|
|Principal Investigator:||Jesper B Poulsen, MD||Rigshospitalet, Denmark|