ACToR-study : Angiographic CT of Renal Transplantation Candidate - Study (ACToR)
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|ClinicalTrials.gov Identifier: NCT01344434|
Recruitment Status : Completed
First Posted : April 29, 2011
Last Update Posted : April 10, 2014
|Condition or disease|
|Renal Transplant Candidate for Right Kidney Renal Transplant Candidate for Left Kidney|
Chronic kidney disease is a known risk factor for cardiovascular disease and cardiovascular disease is the leading cause of mortality in end-stage renal disease (ESRD) patients. After renal transplantation one-half of all deaths are cardiac, usually in the first 5 years in the presence of a functional graft. Because of this renal transplantation candidates are undergoing cardiac pre-transplant risk stratification.
There is no consensus regarding which modality should be use for detection of CAD in this cardiac pre-transplant risk stratification. CAG is known as gold standard but is a invasive procedure with risk of complication.
The investigators wish to investigate the ability of detecting CAD as defined by invasive Coronary angiography (CAG) by clinical examination, blood test and non-invasive test (cCTA, MPS and acoustic CAD Patch). The investigators hypothesize that a single modality or combination of these with high sensitivity and specificity could diagnose significant CAD without the need of further invasive procedures.
This study will include 150 renal transplantations candidate.
|Study Type :||Observational|
|Actual Enrollment :||167 participants|
|Official Title:||Angiographic CT of Renal Transplantation Candidate - Study|
|Study Start Date :||February 2011|
|Actual Primary Completion Date :||February 2014|
|Actual Study Completion Date :||February 2014|
- To investigate the ability of non-invasive tests to detect CAD as defined by invasive angiography in renal transplantation candidates. [ Time Frame: 2013 october ]Baseline results of coronary computed tomographic angiography (cCTA), myocardial perfusion scintigraphy (MPS), acoustic CAD Patch and combination hereof to detect CAD as defined by invasive Coronary angiography (CAG).
- To investigate the risk of Contrast-Induced Nephropathy (CIN) after cCTA and CAG. [ Time Frame: 2013 october ]Blood sample of creatinine after contrast exposure.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01344434
|Aarhus, Denmark, 8200|
|Principal Investigator:||Simon Winther, MD||Department of Cardiology, Skejby Sygehus, Denmark|