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The Effectiveness of Diagnosis and Treatment of Thoracic Outlet Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01342068
Recruitment Status : Completed
First Posted : April 26, 2011
Last Update Posted : April 25, 2013
Information provided by (Responsible Party):
Yasmin Qureshi, MHS, MSPT, Nova Southeastern University

Brief Summary:

Thoracic Outlet Syndrome (TOS) is a condition causing numbness, tingling and weakness in patient's upper limbs. Symptoms are due to compression and restriction of the nerves and blood vessels (neurovascular bundle) that extend from the neck into the upper limb exerted by a patient's various anatomical structures. Neurovascular bundle compression can result in decreased nerve conduction and blood flow through the arteries supplying structures downstream from the restricted site. These anatomical restrictions include tight scalene muscles in the neck, tightened pectorialis minor muscle in the chest and extra ribs growing from the C7 vertebra.

TOS can be diagnosed by using special tests designed to re-elicit neurovascular bundle compression. Upon obtaining a positive test, the patient can undergo osteopathic manipulative treatments (OMT) to change the anatomical restrictions allowing for a decrease of symptoms and even eradication of the syndrome altogether.

Although diagnosis and treatment of TOS is common in osteopathic medicine, the effectiveness of the diagnostic special tests and treatment has not been thoroughly investigated. This study aims to examine the effectiveness of the special tests (Adson's, Wright's hyperabduction and Halstead maneuver) in diagnosing a change in blood flow through the arteries of the upper arm compared to evaluation with Doppler ultrasound to measure blood flow while the tests are performed. Patients with positive tests will be treated with OMT including myofascial release, soft tissue, and articulation to relieve restricting structures. Upon completion of treatment, the special tests will be performed again along with the Doppler ultrasound to measure blood flow through blood vessels. Results then are analyzed statistically for significance of the ability correctly diagnose and treat TOS symptoms.

Results from this study will contribute towards the validity of teaching special tests in osteopathic medical schools and allow for a non-invasive treatment protocol for patients with TOS.

Condition or disease
Thoracic Outlet Syndrome

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Study Type : Observational
Actual Enrollment : 31 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: The Effectiveness of Diagnosis and Treatment of Thoracic Outlet Syndrome
Study Start Date : June 2011
Actual Primary Completion Date : April 2013
Actual Study Completion Date : April 2013

Primary Outcome Measures :
  1. Blood flow velocity [ Time Frame: 5 minutes ]
    Doppler ultrasound was utilized to measure blood flow velocity during TOS special tests pre and post osteopathic manipulative treatment.

Information from the National Library of Medicine

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Ages Eligible for Study:   21 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Subjects will be recruited from a variety of settings:

  1. First and second year medical students from Nova Southeastern University College of Osteopathic Medicine with symptoms of Thoracic outlet syndrome.
  2. Patients from the Sanford Ziff Osteopathic Manipulation Clinic that exhibit symptoms of Thoracic outlet syndrome
  3. Patients from the Nova Southeastern University Sports Medicine Clinic that exhibit symptoms of Thoracic outlest syndrome.

Inclusion Criteria:

  • positive Roo's test indicative of thoracic outlet syndrome
  • one positive provocative test for thoracic outlet syndrome from:Adson's, Wright's or Halstead's indicative of the specific tissue that is impeding blood flow to the upper extremity.

Exclusion Criteria:

  • known medical history of cervical disc disease (such as herniated discs, degenerative disc disease
  • known medical history of upper extremity nerve entrapment syndromes such as carpal tunnel syndrome, pronator teres syndrome, anterior interosseus syndrome, ulnar groove, cubital tunnel, Guyon's canal or radial tunnel syndrome.
  • medical history of diabetic/thyroid related neuropathies and medicine induced paresthesias
  • medical history of atherosclerosis or any type of clotting or other vascular disorders such as thromboembolism of the upper extremity
  • excessive pain during Patients with excessive pain during passive shoulder range of motion procedures such as in 'frozen shoulder'

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01342068

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United States, Florida
Nova Southeastern University
Davie, Florida, United States, 33314
Sponsors and Collaborators
Nova Southeastern University
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Principal Investigator: Yasmin Qureshi, DPT Nova Southeastern University
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Responsible Party: Yasmin Qureshi, MHS, MSPT, Assistant Professor, Nova Southeastern University Identifier: NCT01342068    
Other Study ID Numbers: TOS-Dx and Tx
First Posted: April 26, 2011    Key Record Dates
Last Update Posted: April 25, 2013
Last Verified: February 2013
Keywords provided by Yasmin Qureshi, MHS, MSPT, Nova Southeastern University:
Thoracic outlet syndrome
Osteopathic medicine
Osteopathic Manual Manipulations
Wright's Test
Adson's Test
Halstead's Maneuver
Vascular Sonography
Additional relevant MeSH terms:
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Thoracic Outlet Syndrome
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Nerve Compression Syndromes
Peripheral Nervous System Diseases
Neuromuscular Diseases
Nervous System Diseases