Post-exercise Dietary Protein Strategies
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|ClinicalTrials.gov Identifier: NCT01319513|
Recruitment Status : Completed
First Posted : March 21, 2011
Last Update Posted : March 21, 2011
|Condition or disease||Intervention/treatment||Phase|
|Optimal Anabolic Nutrition Interventions||Other: whey protein bolus Other: whey protein pulses||Not Applicable|
The rapid appearance into the blood of essential amino acids, and leucine in particular, may act as an important signal to stimulate muscle protein synthesis after resistance exercise. This may explain why consuming rapidly-absorbed whey protein may have an anabolic edge over slowly-absorbed proteins such as casein. Previous investigations into importance of the rate of absorption to muscle protein synthesis that have used 'fast' and 'slow' proteins have been confounded by differences in amino acid composition. The present study addresses this issue by administering the same protein source, whey, as either a bolus or in small divided 'pulse' doses to achieve divergent amino acid profiles after a bout of resistance exercise.
This study is being conducted in young (18-35) men.
Our outcome measures include: blood amino acid concentrations, rates of myofibrillar protein synthesis, anabolic intracellular signalling markers
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||8 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effect of the Pattern Post-exercise Aminoacidemia on Myofibrillar Protein Synthesis|
|Study Start Date :||July 2009|
|Actual Primary Completion Date :||October 2009|
|Actual Study Completion Date :||October 2009|
Experimental: protein feeding
Participants will complete 2 trials in a cross-over fashion in which they will consume whey protein either as a single bolus or as 10 small divided doses
Other: whey protein bolus
single dose of 25 g whey protein
Other: whey protein pulses
10 2.5 g pulses of whey protein
- Rate of myofibrillar protein synthesis [ Time Frame: 4 months ]Rates of myofibrillar protein synthesis will be measured from muscle biopsy samples obtained from subjects participating in the study protocol.
- Myocellular protein phosphorylation [ Time Frame: 4 months ]Protein phosphorylation of target proteins will be measured from Western blot analysis of muscle biopsy samples.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01319513
|Ivor Wynne Centre A103, McMaster University|
|Hamilton, Ontario, Canada, L8S 4K1|
|Principal Investigator:||Stuart M Phillips, PhD||McMaster University|