Investigation on the Value of Bilateral Index (BIS) Monitoring for Magnetic Seizure Versus Electroconvulsive Therapy
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|ClinicalTrials.gov Identifier: NCT01318018|
Recruitment Status : Completed
First Posted : March 18, 2011
Results First Posted : October 5, 2018
Last Update Posted : October 5, 2018
Electroconvulsive therapy (ECT) has been shown to be an effective treatment for patients suffering from depression, who do not respond to medical treatment. However it is often dismissed by patients, who feel uncomfortably about the application of electric shocks to their heads. In 2000, magnetic seizure therapy (MST) has been introduced which uses magnetism instead of electricity to evoke convulsions. MST seems to be as effective as ECT in terms of its antidepressant potency but may be associated with less severe cognitive side effects.
Control of anaesthesia during seizure therapy is demanding since light anesthesia might be associated with awareness, whereas deep anesthesia impedes the antidepressant effect of the convulsion. Therefore, Bispectral index (BIS) monitoring is frequently used to tailor anaesthesia for ECT, however little is known about BIS following MST.
The investigators hypothesize that in comparing MST with ECT, (a) patients show a faster increase in BIS and that (b)less left-right differences occur in BIS.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Official Title:||Bilateral Bispectral Index Monitoring During and After Electroconvulsive Therapy Compared With Magnetic Seizure Therapy for Treatment-resistant Depression|
|Study Start Date :||February 2011|
|Actual Primary Completion Date :||December 2011|
|Actual Study Completion Date :||February 2012|
Magnetic Seizure Therapy Group
Patients receiving magnetic seizure therapy for depression
Electroconvulsive Therapy Group
Patients receiving electroconvulsive therapy for depression
- Recovery Time [ Time Frame: same day ]recovery time from seizure induction to eye opening / restoration of breathing
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01318018
|Dept. of Anaesthesiology and Intensive Care Medicine & Dept. of Psychiatry and Psychotherapy, University of Bonn Hospital|
|Principal Investigator:||Martin Soehle, MD, PhD||Dept of Anaesthesiology and Intensive Care Medicine|