Riboflavin Corneal Crosslinking for Brittle Cornea Syndrome and Ehlers-Danlos Syndrome Type VI
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ClinicalTrials.gov Identifier: NCT01307527
Recruitment Status : Unknown
Verified February 2011 by Hadassah Medical Organization. Recruitment status was: Enrolling by invitation
Brittle Cornea Syndrome and Ehlers-Danlos Syndrome (EDS) type VI are rare collagen-connective tissue disorders that predispose affected individuals to the development of perforated corneas from the mildest of eye trauma or even spontaneously. Clinical studies evaluating riboflavin-corneal crosslinking have found that it dramatically increases corneal rigidity. Given the success and safety of riboflavin crosslinking, the investigators believe that it can increase the corneal stability in patients affected these disseases, preventing perforation. It is furthermore possible, that riboflavin crosslinking will allow corneal transplants to successfully be performed on blind eyes that have already perforated and opacified. The purpose of the study is to determine whether corneal crosslinking can be safely performed on individuals with Brittle Cornea Syndrome or Ehlers-Danlos Syndrome type VI.
Condition or disease
Brittle Cornea SyndromeEhlers-Danlos Syndrome Type 6
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Adult Patient with:
Genetic diagnosis of either Brittle Cornea Syndrome or EDS-VI, and
Personal History of either spontaneous corneal perforation or corneal perforation due to minor ocular mechanical trauma or
Immediate family member with history of either spontaneous corneal perforation or corneal perforation due to minor ocular mechanical trauma
Any patient that is deemed to be unable to fully cooperate during the crosslinking procedure