Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Resection
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|ClinicalTrials.gov Identifier: NCT01307085|
Recruitment Status : Completed
First Posted : March 2, 2011
Last Update Posted : December 12, 2013
|Condition or disease||Intervention/treatment||Phase|
|Lung Neoplasms||Procedure: remote ischemic preconditioning||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||108 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Investigator, Outcomes Assessor)|
|Official Title:||Effect of Remote Ischemic Preconditioning on Lung Injury in Patients Undergoing Pulmonary Resection:a Randomised Controlled Trial|
|Study Start Date :||February 2011|
|Actual Primary Completion Date :||June 2013|
|Actual Study Completion Date :||June 2013|
Adult patients undergoing elective pulmonary lobectomy were received a remote ischemic preconditioning group after induction of anaesthesia.
Procedure: remote ischemic preconditioning
Remote ischaemic preconditioning consisted of three 5-min cycles of right upper limb ischaemia, induced by an automated cuff-inflator placed on the upper arm and inflated to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated.
Other Name: RIP
No Intervention: conventional
Adult patients undergoing pulmonary lobectomy were received no treatment after induction of anaesthesia.
- Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing pulmonary lobectomy [ Time Frame: June,2013 ]PaO2/FiO2 in the limb RIPC group was significantly higher than that in the control group at 30 and 60 min after OLV, 30 min and 6 h after operation (all P<0.05)
- Cs and Cd [ Time Frame: June,2013 ]Cs and Cd in limb RIPC group were significantly higher than those in the control group at 30 and 60 min after OLV (all P<0.05)
- IL-6 and TNF-α [ Time Frame: June,2013 ]The IL-6 levels in the limb RIPC group were lower than those in the control group at 30 min, 6, 12, 24 and 48 h after operation (all P<0.05), and there was a significant difference in TNF-α level between the groups (P<0.01).
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01307085
|Departmeng of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University|
|GuangZhou, Guangdong, China, 510080|
|Principal Investigator:||Xuan Ke Liu, Ph.d||Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University|