COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Mental Practice Impact on Gait and Cortical Organization in Spinal Cord Injury (SCI)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01302522
Recruitment Status : Completed
First Posted : February 24, 2011
Last Update Posted : February 24, 2011
Information provided by:
University of Cincinnati

Brief Summary:
Spinal cord injury (SCI) is a disabling condition that impairs fundamental abilities, such as ambulation, respiration, and toileting. Compromised ambulation is a common, devastating impairment following SCI. Yet, despite the fundamental desire to walk, no conventional rehabilitation regimen reliably improves ambulation after SCI, and many SCI patients do not have reliable transportation access, decreasing community integration and access to needed services, including rehabilitation. Little is also known about the subtle neural events that may predict motor recovery in incomplete SCI patients. This study will test a novel, safe, easy to implement technique that has shown promise in improving gait in incomplete SCI patients. The investigators expect that this study will confirm the efficacy of this technique, by showing that it increases the speed and efficiency of walking. This outcome is expected to produce a therapy that improves outcomes and health, and reduces care costs, for community dwelling patients with incomplete SCI.

Condition or disease Intervention/treatment Phase
Incomplete Spinal Cord Injury Behavioral: Mental practice Phase 2

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Mental Practice Impact on Gait and Cortical Organization in SCI
Study Start Date : September 2008
Actual Primary Completion Date : July 2010
Actual Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

Intervention Details:
  • Behavioral: Mental practice
    All patients in the study will be administered a regimen of locomotor therapy (rehabilitative therapy working on walking). Half of the patients will also be administered a regimen in which they mentally rehearse the exercises that they have just physically performed.
    Other Name: Motor imagery

Primary Outcome Measures :
  1. Gait velocity: The investigators are measuring the speed that people walk. [ Time Frame: 1-3 weeks before intervention; 1 week after intervention; 3 months after intervention ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • age > 18 years old;
  • incomplete SCI (ASIA Grade C or D), experienced > 1 year prior to enrollment;
  • motor grade of > 1 < 3 in the quads, hamstrings, and hip flexors, and ability to ambulate with at least a maximal assist;
  • range of motion in the lower limbs within functional limits;
  • motor function in at least half of ASIA key lower extremity muscles with strength < or > 3/5;
  • able to ambulate at least 10 meters with 1 person assistance and/or assistive device;
  • medically stable (ie, no bladder infection; decubiti); (8) stable dosage of antispasticity medications for duration of study

Exclusion Criteria:

  • excessive spasticity in the lower limbs as measured by a score of > 3 on the Modified Ashworth Spasticity Scale;
  • excessive pain in the lower limbs as measured by a score of > 5 on a Visual Analog Scale or > 8/10 with a clarified scaled picture graph;
  • moderate to severe osteoporosis, as indicated by the patient's physician;
  • heterotropic ossification, as indicated by the patient's physician;
  • psychological conditions that would contraindicate participation in the program and no abnormalities of attention, with minimum cognitive capacity present sufficient to participate in MP;
  • fracture or fracture history in the lower limbs (individuals with a remote history of fractures may be included at discretion of the study physical therapists at each site);
  • enrolled in any form of rehabilitation;
  • for subjects to be administered fMRI, implant containing electrical circuitry, generating electrical signals, or having moving metal parts, metal pins or plates above the waist, orthodontic braces, or other positives on a standard checklist of MRI exclusion criteria used by the Radiology Department;
  • pregnant;
  • DSM-IV Major Depressive Episode symptom criteria of > 5/9 as exclusion threshold instead of CESD;
Layout table for additonal information
Responsible Party: Stephen Page, PhD, University of Cincinnati Identifier: NCT01302522    
Other Study ID Numbers: 1R21AT003842-01 ( U.S. NIH Grant/Contract )
First Posted: February 24, 2011    Key Record Dates
Last Update Posted: February 24, 2011
Last Verified: February 2011
Additional relevant MeSH terms:
Layout table for MeSH terms
Spinal Cord Injuries
Wounds and Injuries
Spinal Cord Diseases
Central Nervous System Diseases
Nervous System Diseases
Trauma, Nervous System