Effect of NAVA on Weaning Duration in Difficult to Wean Patients
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|ClinicalTrials.gov Identifier: NCT01280773|
Recruitment Status : Completed
First Posted : January 21, 2011
Last Update Posted : October 16, 2018
|Condition or disease||Intervention/treatment||Phase|
|Weaning||Device: NAVA||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||99 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Department of Critical Care Medicine, Nanjing Zhong-Da Hospital, Southeast University School of Medicine, China; Department of Critical Care Medicine St. Michaels's Hospital, University of Toronto, Canada|
|Actual Study Start Date :||September 30, 2011|
|Actual Primary Completion Date :||October 1, 2017|
|Actual Study Completion Date :||October 1, 2018|
No Intervention: PSV weaning
Patinens in the PSV group will be weaned using PSV mode.
Experimental: NAVA weaning
Patients in NAVA group will eb weaned using NAVA mode.
Neurally adjusted ventilatory assist (NAVA) was delivered by a SVi ventilator. NAVA utilizes EAdi, a reflection of the neural respiratory output to diaphragm, as its primary source to trigger and cycle-off assist in synchrony with neural inspiratory efforts.
- Duration of weaning [ Time Frame: 48h after extubation ]Duration of weaning was defined as time from study enrollment to extubation.
- Extubation rate [ Time Frame: 48h after extubation or 30 day after enrollment ]Extubation rate was defined as the percentage of patients with successful weaning
- diaphragmatic function [ Time Frame: At 8 am daily before extubatiuon ]Diaphragmatic function was measured by neuro-ventilatory efficiency (NVE), a ratio of tidal volume to diaphragm electrical activity (Vt/EAdi), and neuro-mechanical efficiency (NME), a ratio of airway pressure to EAdi(Paw/EAdi) during airway occlusion. diaphragmatic function
- Patient ventilator asynchrony [ Time Frame: At 8 am daily until extubation ]Time delay between neuro inspiration and ventilator delivery. Time delay between neuro expiration and ventilator cycle-off.
- Mortality [ Time Frame: ICU or hospital discharge or 28day ]ICU, 28 day and hospital mortality
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01280773
|Nanjing Zhong-Da Hospital|
|Nanjing, Jiangsu, China, 210009|
|Study Director:||Haibo Qiu, PhD,MD||Southeast University|