Methods for Objective Selection of Competent Sperm (MACS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01265329
Recruitment Status : Completed
First Posted : December 23, 2010
Last Update Posted : August 5, 2014
Information provided by (Responsible Party):
Marcos Meseguer, Instituto Valenciano de Infertilidad, IVI VALENCIA

Brief Summary:

In spite of the achievements and developement of the assisted reproduction techniques in the last years, there is still an elevated percentage of unsuccessful treatments, needing sometimes repeated attempts to reach pregnancy.

The molecular physiology of sperm is being better characterized, and some reports have demonstrated the implication of different molecular processes in the pathophysiology of male infertility.

Recently, different sperm selection methods have been based on these molecular differences, showing a better quality of the sperm population after selection.

The main objective of this research project is to clinically apply these techniques in order to increase the pregnancy rates per cycle in infertile couples attending assisted reproduction treatments.

Condition or disease Intervention/treatment Phase
Sperm Selection Other: Negative selection Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 237 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary Purpose: Treatment
Study Start Date : October 2010
Actual Primary Completion Date : December 2012
Actual Study Completion Date : December 2012

Arm Intervention/treatment
No Intervention: Control
No sperm selection
Experimental: Annexine V negative
Sperm selection with Annexine V protein
Other: Negative selection
Sperm selection to continue the treatment with healthy sperm

Primary Outcome Measures :
  1. Gestation [ Time Frame: 14 days ]
    Sperm selection and blood sample confirming gestation

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 37 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:


- >3million sperm after swimming process


  • < 37 YEARS OLD

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01265329

IVI Valencia
Valencia, Spain, 46015
Sponsors and Collaborators
Instituto Valenciano de Infertilidad, IVI VALENCIA
Principal Investigator: Nicolas Garrido, PhD IVI Valencia

Responsible Party: Marcos Meseguer, Embryologist IVI Valencia, Instituto Valenciano de Infertilidad, IVI VALENCIA Identifier: NCT01265329     History of Changes
Other Study ID Numbers: 0810-C-051-MM
First Posted: December 23, 2010    Key Record Dates
Last Update Posted: August 5, 2014
Last Verified: August 2014