Methods for Objective Selection of Competent Sperm (MACS)
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|ClinicalTrials.gov Identifier: NCT01265329|
Recruitment Status : Completed
First Posted : December 23, 2010
Last Update Posted : August 5, 2014
In spite of the achievements and developement of the assisted reproduction techniques in the last years, there is still an elevated percentage of unsuccessful treatments, needing sometimes repeated attempts to reach pregnancy.
The molecular physiology of sperm is being better characterized, and some reports have demonstrated the implication of different molecular processes in the pathophysiology of male infertility.
Recently, different sperm selection methods have been based on these molecular differences, showing a better quality of the sperm population after selection.
The main objective of this research project is to clinically apply these techniques in order to increase the pregnancy rates per cycle in infertile couples attending assisted reproduction treatments.
|Condition or disease||Intervention/treatment||Phase|
|Sperm Selection||Other: Negative selection||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||237 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Outcomes Assessor)|
|Study Start Date :||October 2010|
|Actual Primary Completion Date :||December 2012|
|Actual Study Completion Date :||December 2012|
No Intervention: Control
No sperm selection
Experimental: Annexine V negative
Sperm selection with Annexine V protein
Other: Negative selection
Sperm selection to continue the treatment with healthy sperm
- Gestation [ Time Frame: 14 days ]Sperm selection and blood sample confirming gestation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01265329
|Valencia, Spain, 46015|
|Principal Investigator:||Nicolas Garrido, PhD||IVI Valencia|