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Nerve Growth Factor in Chronic Pancreatitis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01255917
Recruitment Status : Completed
First Posted : December 8, 2010
Last Update Posted : March 7, 2016
Stanford University
Information provided by (Responsible Party):
Virginia Commonwealth University

Brief Summary:

This study is to understand the role of nerve growth factor(NGF) and other cytokines in the pancreatic fluid of patients with chronic pancreatitis.


  1. Pain does not correlate with changes in the PD morphology suggesting that pain in CP is not only a mechanical problem
  2. Pain in CP correlates better with the levels of NGF in the pancreatic juice. NGF is variably expressed in different morphological stages of CP and regulates the sensitivity of the peptidergic nociceptors and is upregulated in pancreatic inflammation.

Condition or disease
Chronic Pancreatitis

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Study Type : Observational
Actual Enrollment : 38 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Nerve Growth Factor in Chronic Pancreatitis
Study Start Date : February 2008
Actual Primary Completion Date : August 2011
Actual Study Completion Date : August 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pancreatitis

Chronic pancreatitis

Primary Outcome Measures :
  1. The levels of NGF in subjects with different morphological stages of chronic pancreatitis (CP) will be compared to the controls and in each morphological stage of CP will be correlated with pain scores. [ Time Frame: 5 years ]

Secondary Outcome Measures :
  1. Correlate the expression of NGF and other inflammatory cytokines in the pancreatic juice in each morphological stage of CP. [ Time Frame: 5 years ]

Biospecimen Retention:   Samples Without DNA
Pancreatic fluid obtained by duodenal aspiration

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Test group: Subjects with CP in each morphological stage and matched for age, race, gender, narcotic dependence and etiology of CP will be enrolled Controls: Subjects undergoing upper gastrointestinal endoscopy (UGIE) for non-pancreatic causes.

Inclusion Criteria:

  • Patients with established CP and none of the exclusion criteria mention below.

Exclusion Criteria:

  • Failure to obtain consent.
  • Any comorbid condition with expected survival < 1 year.
  • Patients with pacemaker, implanted metallic prosthesis or other contraindications to do MRCP.
  • Patients < 18 years of age at time of consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01255917

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United States, Virginia
Virginia Commonwealth University Medical Center
Richmond, Virginia, United States, 23298
Sponsors and Collaborators
Virginia Commonwealth University
Stanford University
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Principal Investigator: Bimaljit S Sandhu, M.D Associate Professor, VCU Medical Center
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Responsible Party: Virginia Commonwealth University Identifier: NCT01255917    
Other Study ID Numbers: HM11033
First Posted: December 8, 2010    Key Record Dates
Last Update Posted: March 7, 2016
Last Verified: March 2016
Keywords provided by Virginia Commonwealth University:
Tio identify role of NGF in pain in CP
Identify biomarkers related to progression of CP
Additional relevant MeSH terms:
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Pancreatitis, Chronic
Pancreatic Diseases
Digestive System Diseases