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The Sinonasal Outcome Test - 22, Validated for Danish Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01254916
Recruitment Status : Completed
First Posted : December 7, 2010
Last Update Posted : May 8, 2012
Information provided by (Responsible Party):
Bibi Lange, Odense University Hospital

Brief Summary:

Introduction: Chronic rhinosinusitis (CRS) is a significant health problem increasing in both incidence and prevalence. It calls into attention consensus about diagnosing, assessing symptoms and treatment of patients with CRS. Therefore a validated Danish measure of health-related quality of life in sinonasal disease is needed.

Method: The Sinonasal Outcome measure 22 (SNOT-22) was translated into Danish and reproducibility was evaluated by test-retesting 40 patients with CRS. The statistical analyses used, were Pearson´s correlation coefficient, Cronbach´s alfa, Kappa and Bland-Altman´s Plot. Reproducibility was also tested looking at subscales within the SNOT-22.

Result: The results show good internal correlation with Cronbach´s alfa at 0.83 in the initial test and 0.92 in the retest. Pearson was 0.70 (p<0.001) revealing good correlation between the initial scores and the retests scores. Kappa was calculated for each item with a mean value of 0.61 showing substantial agreement. Paired t-test revealed no significant difference in the subscales.

Conclusion: The Danish version of SNOT-22 is recommended for Danish clinicians and researches as a patient-reported measure of outcome in sino-nasal disorders such as rhinosinusitis and nasal polyposis.

Condition or disease
Chronic Rhinosinusitis

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Study Type : Observational
Actual Enrollment : 44 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Sinonasal Outcome Test - 22, Validated for Danish Patients
Study Start Date : October 2008
Actual Primary Completion Date : March 2009
Actual Study Completion Date : March 2009

Patients with chronic rhinosinusitis

Primary Outcome Measures :
  1. Reproducibility of Sinonasal Outcome test 22 [ Time Frame: From the time of fullfilling the first SNOT-22 to fullfilling the second SNOT-22 after 14 days ]

Information from the National Library of Medicine

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Ages Eligible for Study:   15 Years to 75 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with chronic rhinosinusitis diagnosed by a medical doctor

Inclusion Criteria: Persons diagnosed with Chronic Rhinosinusitis -

Exclusion Criteria: Change of treatment or acute change of symptoms due to common cold/influenza in the time between completing the test and the retest. If SNOT-score was very low. Persons who left before offered test or declined testing.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01254916

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Department of Otorhinolaryngology, Odense University Hopsital
Odense, Denmark, DK-5000
Sponsors and Collaborators
Odense University Hospital
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Bibi Lange, MD, Ph.d.-student, Odense University Hospital Identifier: NCT01254916    
Other Study ID Numbers: Danish SNOT 22
First Posted: December 7, 2010    Key Record Dates
Last Update Posted: May 8, 2012
Last Verified: May 2012
Keywords provided by Bibi Lange, Odense University Hospital:
Chronic Rhinosinusitis
Sinonasal Outcome test 22