Cytokine Changes After Colorectal Cancer Resection
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|ClinicalTrials.gov Identifier: NCT01244022|
Recruitment Status : Completed
First Posted : November 19, 2010
Last Update Posted : July 16, 2013
|Condition or disease||Intervention/treatment|
|Colorectal Cancer||Procedure: colorectal cancer resection|
Every surgical intervention represents a stress for patient's organism. During the operation, numerous changes in the patient's metabolism take place, that are termed surgical stress response. Leading cause of surgical stress response is tissue destruction that always accompanies operations. Surgical stress response is effected through activation of hypothalamus-pituitary-adrenal axis and through sympathetic activation.
The consequences of surgical stress response are numerous. Surgical stress response is essential to uneventful postoperative recovery. On the other hand, excessive surgical stress response may lead to serious postoperative complications, such as heart and kidney failure, venous thrombosis, disruption of operative wound and wound infection.
In prior studies the investigators have shown the kinetics of postoperative serum interleukin changes after radical resection of gastric cancer.
This study aims at determining reliable markers of surgical stress response severity in patients undergoing radical resection of colorectal cancer.
|Study Type :||Observational|
|Actual Enrollment :||28 participants|
|Official Title:||Postoperative Serum Cytokine Changes After Radical Resection of Colorectal Cancer|
|Study Start Date :||August 2010|
|Actual Primary Completion Date :||December 2012|
|Actual Study Completion Date :||December 2012|
Colorectal cancer patients
Patients with pathohistologically verified colorectal cancer or adenoma with epithelial dysplasia
Procedure: colorectal cancer resection
Open radical resection of colorectal cancer, according to oncological principals, depending on the tumor site
- Postoperative changes of serum cytokine levels [ Time Frame: 1 day, 2 days and 7 days postoperatively ]Serum cytokine levels will be determined at 1st, 2nd and 7th postoperative day and compared to preoperative values.
- Early postoperative complications [ Time Frame: Within one month after surgery ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01244022
|University Hospital Dubrava|
|Zagreb, Croatia, 10000|
|Principal Investigator:||Drazen Servis, M.D., Ph.D.||University Hospital Dubrava|