Polarization Sensitive Retinal Tomography for Glaucoma Diagnosis (PSOCT)
The proposed human clinical studies have three main objectives:
- To determine reproducibility of peripapillary birefringence maps and identify features that measure the health of the RNFL.
- To determine the normal variation in the birefringence maps with age.
- To develop and test a classifier for glaucoma based on the birefringence maps using a case-control clinical trial.
This study is a case-control study intended to optimize feature selection for a future multi-center blinded study. The proposed clinical study does not measure conversion from normal to glaucoma.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Polarization Sensitive Retinal Tomography for Glaucoma Diagnosis|
- Sensitivity/specificity of PSOCT to classify glaucoma vs. non-glaucoma [ Time Frame: The time frame to assess the effectiveness of the diagnostic algorithm is 1 year ] [ Designated as safety issue: No ]Features from RNFL phase retardation and birefringence maps will be combined into a diagnostic algorithm to differentiate glaucoma vs. non-glaucoma
|Study Start Date:||August 2007|
|Study Completion Date:||March 2011|
|Primary Completion Date:||December 2010 (Final data collection date for primary outcome measure)|
Two groups will be studies: patients with glaucomatous visual field loss and age and gender matched normal patients without visual field loss
Please refer to this study by its ClinicalTrials.gov identifier: NCT01222065
|United States, Texas|
|Eye Institute of Austin|
|Austin, Texas, United States, 78757|
|Principal Investigator:||Henry G Rylander, MD||University of Texas at Austin|