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Reference Values of Cerebrospinal Fluid Outflow Resistance and Intracranial Pressure in Healthy Elderly

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01188382
Recruitment Status : Completed
First Posted : August 25, 2010
Last Update Posted : August 25, 2010
Information provided by:
Umeå University

Brief Summary:

Objective. The intracranial pressure and cerebrospinal outflow resistance are essential parameters to describe the cerebrospinal fluid dynamic system. Outflow resistance effects intracranial pressure, pulse amplitudes, cerebrospinal fluid absorption as well as the compliance of the system. The objective of this study was to determine the reference values in the elderly.

Methods. Elderly people (60-82 years), considering themselves healthy, were recruited through an ad in the local paper. All were evaluated with a 3 Tesla magnetic resonance imaging apparatus. Subjects were eligible if they did not have any psychiatric or neurological disorder or signs of advanced atherosclerotic disease. Intracranial pressure and outflow resistance were determined by a constant pressure infusion method with the patient in the supine position. The study population consisted of 40 subjects (mean age 70 years; 23 women).

Condition or disease Intervention/treatment
Healthy Elderly Procedure: CSF dynamic investigation

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Study Type : Observational
Actual Enrollment : 40 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Reference Values of Cerebrospinal Fluid Outflow Resistance and Intracranial Pressure in Healthy Elderly
Study Start Date : August 2007
Actual Primary Completion Date : December 2008
Actual Study Completion Date : December 2008

Group/Cohort Intervention/treatment
Healthy elderly
Healthy elderly 60-82 years; Normal MRI; No psychiatric or neurological disorder and without signs of advanced atherosclerotic disease
Procedure: CSF dynamic investigation

Primary Outcome Measures :
  1. CSF outflow resistance

Secondary Outcome Measures :
  1. Intracranial pressure

Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years to 82 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy elderly

Inclusion Criteria:

  • Healthy
  • 60-82 years

Exclusion Criteria:

  • Psychiatric or neurological disorder or advanced atherosclerotic disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01188382

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Dep Clincial Neuroscience, Umeå university
Umeå, Sweden, 901 85
Sponsors and Collaborators
Umeå University
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Principal Investigator: Jan I Malm, PhD, MD Umeå University

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Jan Malm, Dep Clinical Neuroscience Identifier: NCT01188382    
Other Study ID Numbers: Hydrocephalus100
First Posted: August 25, 2010    Key Record Dates
Last Update Posted: August 25, 2010
Last Verified: June 2010
Keywords provided by Umeå University:
Intracranial pressure
CSF outflow
reference value