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Efficacy of Methylsulfonylmethane Supplementation on Osteoarthritis of The Knee: A Randomized Controlled Study

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ClinicalTrials.gov Identifier: NCT01188213
Recruitment Status : Completed
First Posted : August 25, 2010
Last Update Posted : August 25, 2010
Information provided by:
Assaf-Harofeh Medical Center

Brief Summary:
The aim of this study was to determine the efficacy of methylsulfonylmethane (MSM) in treating patients with knee OA.

Condition or disease Intervention/treatment Phase
Knee Osteoarthritis Dietary Supplement: Methylsulfonylmethane (MSM) Not Applicable

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Study Type : Interventional  (Clinical Trial)

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Osteoarthritis

Arm Intervention/treatment
Experimental: Purified MSM Dietary Supplement: Methylsulfonylmethane (MSM)

Primary Outcome Measures :
  1. WOMAC questionnaire

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • symptomatic knee OA for at least 6 months according to the clinical criteria of the American College of Rheumatology (ACR)
  • radiographic confirmed knee OA according to the Kellgren & Lawrence scale

Exclusion Criteria:

  • acute septic arthritis
  • inflammatory arthritis
  • any other type of arthritis
  • history of knee buckling or recent knee injury
  • lack of physical or mental bility to perform or comply with the treatment procedure
  • diabetes mellitus
  • fibromyalgia or other chronic pain syndromes
  • concurrent anti-coagulant/anti-platelet drugs
  • arthroscopy or intra-articular injections in the previous 3 months
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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ClinicalTrials.gov Identifier: NCT01188213    
Other Study ID Numbers: 13/05
First Posted: August 25, 2010    Key Record Dates
Last Update Posted: August 25, 2010
Last Verified: May 2005
Additional relevant MeSH terms:
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Osteoarthritis, Knee
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Dimethyl sulfone
Anti-Inflammatory Agents