Static Graviceptive Functions in Patients With Cervical Dystonia (CD)
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ClinicalTrials.gov Identifier: NCT01180270 |
Recruitment Status :
Completed
First Posted : August 12, 2010
Last Update Posted : January 31, 2012
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Condition or disease |
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Cervical Dystonia |

Study Type : | Observational |
Actual Enrollment : | 45 participants |
Time Perspective: | Prospective |
Official Title: | Experimental Pilot Trial Assessing Static Graviceptive Function in Patients With Cervical Dystonia |
Study Start Date : | June 2010 |
Actual Primary Completion Date : | January 2012 |
Actual Study Completion Date : | January 2012 |
Group/Cohort |
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Cervical dystonia
patients suffering from cervical dystonia under routine botulinum toxin treatment |
healthy volunteers
control group
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- Subjective visual vertical (SVV), measured in degree (°) [ Time Frame: screening ]Assessment: sitting upright in dark room, head is fixed using a head holder with a strap and a neck rest covering the occiput and posterior neck. For deviation of head (0°, 15° and 30° to the left and right side), head holder can be rotated about its midpoint. In front of patient (distance of 100 cm) is dim light bar, which can be rotated about its midpoint by means of an electronic motor and a remote control device. Patients adjust bar for parallel alignment with the perceived gravitational vertical. The operator tilts the bar in a random order 18° from the physical vertical.
- SVV in degree (°) [ Time Frame: 3 weeks after screeening ]Assessment: sitting upright in dark room, head is fixed using a head holder with a strap and a neck rest covering the occiput and posterior neck. For deviation of head (0°, 15° and 30° to the left and right side), head holder can be rotated about its midpoint. In front of patient (distance of 100 cm) is dim light bar, which can be rotated about its midpoint by means of an electronic motor and a remote control device. Patients adjust bar for parallel alignment with the perceived gravitational vertical. The operator tilts the bar in a random order 18° from the physical vertical.
- SVV in degree (°) [ Time Frame: 9 weeks after screening ]Assessment: sitting upright in dark room, head is fixed using a head holder with a strap and a neck rest covering the occiput and posterior neck. For deviation of head (0°, 15° and 30° to the left and right side), head holder can be rotated about its midpoint. In front of patient (distance of 100 cm) is dim light bar, which can be rotated about its midpoint by means of an electronic motor and a remote control device. Patients adjust bar for parallel alignment with the perceived gravitational vertical. The operator tilts the bar in a random order 18° from the physical vertical.
- Degree of head deviation (°) [ Time Frame: screening ]head deviation of patients group in relaxed posture, measured in degrees (°)
- degree of head deviation (°) [ Time Frame: 3 weeks after screening ]head deviation of patients group in relaxed posture, measured in degrees (°)
- degree of head deviation (°) [ Time Frame: 9 weeks after screening ]head deviation of patients group in relaxed posture, measured in degrees (°)

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Ages Eligible for Study: | 18 Years to 80 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Idiopathic CD and willing to participate on the study,
- Isolated laterocollis or laterocollis and torticollis with maximum of 15°rotation
- Aged 18-80 years,
- Under routine treatment with botulinum toxin
Exclusion Criteria:
Patients and Control
- History of vestibular disorders
Patients
- Torticollis with >15°rotation
- Secondary CD (structural MRI lesions, Mb. Wilson)
- Contraindication for intramuscular botulinum toxin therapy: bleeding disorder or anticoagulation therapy

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01180270
Austria | |
Department of neurology, Medical University of Vienna | |
Vienna, Austria, 1090 |
Responsible Party: | Kirsten Elwischger, MD, Medical University of Vienna |
ClinicalTrials.gov Identifier: | NCT01180270 |
Other Study ID Numbers: |
SVV_CD1 |
First Posted: | August 12, 2010 Key Record Dates |
Last Update Posted: | January 31, 2012 |
Last Verified: | January 2012 |
Cervical dystonia torticollis spasmodicus botulinum toxin |
Subjective visual vertical (SVV) SVV static graviceptive function |
Dystonia Dystonic Disorders Torticollis Dyskinesias |
Neurologic Manifestations Nervous System Diseases Movement Disorders Central Nervous System Diseases |